Chek2 - checkpoint kinase 2 Gene

中文名称：检查点激酶 2

种属: Rattus norvegicus

同用名: Chk2; Rad53

关于 Chek2

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。涉及多个过程，包括细胞对双酚 A 的反应；失巢凋亡的正向调节；和细胞周期相变的调节。位于核内。膀胱癌的生物标志物。该基因的人类直系同源物与多种疾病有关，包括 Li-Fraumeni 综合征 2；乳腺癌（多发性）；结直肠癌；骨肉瘤;和前列腺癌。与人类 CHEK2（检查点激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to bisphenol A; positive regulation of anoikis; and regulation of cell cycle phase transition. Located in nucleus. Biomarker of urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast Cancer (multiple); colorectal cancer; osteosarcoma; and prostate Cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Apr 2022]