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  2. CGB2 - chorionic gonadotropin subunit beta 2 Gene

CGB2 - chorionic gonadotropin subunit beta 2 Gene


种属: Homo sapiens

基因 ID: 114336 | 基因类型: protein coding

关于 CGB2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,031,890-49,033,238 (from NCBI)

This gene has 2 transcripts (splice variants), 36 orthologues and 9 paralogues. Restricted expression toward placenta (RPKM 15.8).


绒毛膜促性腺激素 (CGB) 的 β 亚基由六个高度同源且结构相似的基因编码,这些基因以串联和反向对排列在染色体 19q13.3 上,并与黄体生成素 β (LHB) 亚基基因相邻。 CGB 基因的主要区别在于 5' 非转录区的差异。该基因最初被认为是 CGB 亚基的两个假基因 (CGB1 和 CGB2) 之一,然而,在体内检测到 CGB1 和 CGB2 转录本,以及它们在多核糖体上的存在,表明这些转录本被翻译。迄今为止,尚未分离出对应于 CGB2 的蛋白质产物。 132 aa 假设蛋白质的推导序列与功能性 CGB 亚基 (PMID:8954017) 没有任何相似性。然而,从不同框架翻译而来的 163 aa 蛋白质大小大致相同,并且与其他 CGB 亚基具有 98% 的同一性。[RefSeq 提供,2008 年 7 月]

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

CGB2 基因产物(2)

mRNA Protein Name
NM_001319065.2 NP_001305994.1 choriogonadotropin subunit beta variant 2 isoform 2
NM_033378.2 NP_203696.2 choriogonadotropin subunit beta variant 2 isoform 1 precursor

CGB2 蛋白结构


Cys_knot: Cystine-knot domain (25 - 128)

  • 0
  • 100
  • 163 a.a.
蛋白主名 其他名称

choriogonadotropin subunit beta variant 2

chorionic gonadotropin beta subunit 2


种属 基因名 来源 基因 ID
Mus musculus CGB2 MGD MGI:96782