Becn1 - beclin 1 Gene

中文名称：beclin 1

种属: Rattus norvegicus

同用名: Beclin1

关于 Becn1

功能概要

该基因编码的蛋白可启动泛素蛋白连接酶结合活性。参与多个过程，包括细胞对金属离子的反应；细胞凋亡过程的调节；和液泡组织的调节。位于细胞质中；树突;和核。与跨高尔基网络共定位。用于研究脑缺血和大脑中动脉梗塞。多种疾病的生物标志物，包括 Barrett 食管；急性坏死性胰腺炎;动脉疾病（多发性）；脑部疾病（多种）；和神经病（多种）。该基因的人类直系同源物与马查多-约瑟夫病有关。与人类 BECN1 (beclin 1) 同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]