1. Gene
  2. Becn1 - beclin 1 Gene

Becn1 - beclin 1 Gene

中文名称:beclin 1

种属: Rattus norvegicus

同用名: Beclin1

基因 ID: 114558 | 基因类型: protein coding

关于 Becn1

Primary_assembly 10: 86,231,388-86,246,742 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 63 phenotypes. Biased expression in Kidney (RPKM 276.8), Thymus (RPKM 266.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动泛素蛋白连接酶结合活性。参与多个过程,包括细胞对金属离子的反应;细胞凋亡过程的调节;和液泡组织的调节。位于细胞质中;树突;和核。与跨高尔基网络共定位。用于研究脑缺血和大脑中动脉梗塞。多种疾病的生物标志物,包括 Barrett 食管;急性坏死性胰腺炎;动脉疾病(多发性);脑部疾病(多种);和神经病(多种)。该基因的人类直系同源物与马查多-约瑟夫病有关。与人类 BECN1 (beclin 1) 同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 基因产物(2)

mRNA Protein Name
NM_053739.2 NP_446191.1 beclin-1
NM_001034117.1 NP_001029289.1 beclin-1

Becn1 蛋白结构

BH3

BH3: pfam15285 (104 - 126)

APG6_N

APG6_N: pfam17675 (132 - 258)

APG6

APG6: pfam04111 (264 - 442)

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  • 448 a.a.
蛋白主名 其他名称

beclin-1

beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)

beclin 1, autophagy related

coiled-coil myosin-like BCL2-interacting protein

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Becn1 NCBI NCBI:8678