ARHGEF25 - Rho guanine nucleotide exchange factor 25 Gene

中文名称：Rho 鸟嘌呤核苷酸交换因子 25

种属: Homo sapiens

同用名: GEFT; p63RhoGEF

关于 ARHGEF25

功能概要

Rho GTPases 在不活跃的 GDP 结合状态和活跃的 GTP 结合状态之间交替，而 GEF 促进 GDP/GTP 交换。该基因编码一种鸟嘌呤核苷酸交换因子 (GEF) ，它与参与血管平滑肌收缩、血管紧张素 II 反应调节和晶状体细胞分化的 Rho GTP 酶相互作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 1 月]

Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]