2. Gene
  3. DIS3L - DIS3 like exosome 3'-5' exoribonuclease Gene

DIS3L - DIS3 like exosome 3'-5' exoribonuclease Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DIS3 样外泌体 3'-5' 核糖核酸外切酶

种属: Homo sapiens

同用名: DIS3L1

基因 ID: 115752 | 基因类型: protein coding

关于 DIS3L

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,293,309-66,333,898 (from NCBI)

This gene has 14 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 25 other tissues.

功能概要

细胞质 RNA 外泌体复合物降解不稳定的 mRNA，并参与其他 mRNA 的定期更新。该基因编码的蛋白质含有 3'-5' 核糖核酸外切酶活性，是该复合物的催化成分。[RefSeq 提供，2016 年 5 月]

The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

DIS3L 基因产物(13)

mRNA Protein Name
NM_001143688.3 NP_001137160.1 DIS3-like exonuclease 1 isoform 1
NM_001323936.2 NP_001310865.1 DIS3-like exonuclease 1 isoform 2
NM_001323937.2 NP_001310866.1 DIS3-like exonuclease 1 isoform 5
NM_001323938.2 NP_001310867.1 DIS3-like exonuclease 1 isoform 3
NM_001323939.2 NP_001310868.1 DIS3-like exonuclease 1 isoform 3
NM_001323940.2 NP_001310869.1 DIS3-like exonuclease 1 isoform 4
NM_001323941.2 NP_001310870.1 DIS3-like exonuclease 1 isoform 3
NM_001323943.2 NP_001310872.1 DIS3-like exonuclease 1 isoform 4
NM_001323944.2 NP_001310873.1 DIS3-like exonuclease 1 isoform 6
NM_001323945.2 NP_001310874.1 DIS3-like exonuclease 1 isoform 2
NM_001323946.2 NP_001310875.1 DIS3-like exonuclease 1 isoform 3
NM_001323948.2 NP_001310877.1 DIS3-like exonuclease 1 isoform 7
NM_133375.5 NP_588616.1 DIS3-like exonuclease 1 isoform 2

DIS3L 蛋白结构

RNB

RNB: RNB domain (465 - 816)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1054 a.a.
蛋白主名 其他名称

DIS3-like exonuclease 1

DIS3 mitotic control homolog-like

关联疾病

疾病名称 别名
Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor

PRLMNS

Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism

Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor

Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor

Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor

Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism

Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome

Renal Hamartomas Nephroblastomatosis And Fetal Gigantism

Nephroblastoma

Fetal Macrosomia
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Trichohepatoenteric Syndrome 2

THES2
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03779 DIS3L Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03780 DIS3L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DIS3L MGD MGI:2143272
Bos taurus DIS3L VGNC VGNC:28073
Canis familiaris DIS3L VGNC VGNC:39963
Macaca mulatta DIS3L VGNC VGNC:71796
Rattus norvegicus DIS3L RGD RGD:1308959
Felis catus DIS3L VGNC VGNC:61500
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