2. Gene
  3. CLNK - cytokine dependent hematopoietic cell linker Gene

CLNK - cytokine dependent hematopoietic cell linker Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞因子依赖性造血细胞接头

种属: Homo sapiens

同用名: MIST

基因 ID: 116449 | 基因类型: protein coding

关于 CLNK

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:10,486,395-10,734,846 (from NCBI)

This gene has 3 transcripts (splice variants), 122 orthologues and 3 paralogues. Biased expression in kidney (RPKM 1.1), lymph node (RPKM 0.5) and 12 other tissues.

功能概要

MIST 是 SLP76 适配器系列的成员 (参见 LCP2，MIM 601603；BLNK，MIM 604515) 。 MIST 在免疫受体信号的调节中发挥作用，包括 PLC-γ (PLCG1；MIM 172420) 介导的 B 细胞抗原受体 (BCR) 信号和 FC-epsilon R1 (参见 FCER1A，MIM 147140) 介导的肥大细胞脱颗粒 (Cao 等，1999 [PubMed 10562326]；Goitsuka 等，2000、2001 [PubMed 10744659] [PubMed 11463797]) .[OMIM 提供，2008 年 3 月]

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

CLNK 基因产物(1)

mRNA Protein Name
NM_052964.4 NP_443196.2 cytokine-dependent hematopoietic cell linker

CLNK 蛋白结构

SH2

SH2: SH2 domain (309 - 392)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
蛋白主名 其他名称

cytokine-dependent hematopoietic cell linker

mast cell immunoreceptor signal transducer

关联疾病

疾病名称 别名
Leukodystrophy, Hypomyelinating, 6

Habc

Hypomyelinating Leukodystrophy 6

HLD6

H-Abc

Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

HLD

Leukodystrophy, Hypomyelinating, Type 6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158820 Cosdosiran / 否
HY-158820A Cosdosiran sodium / 否
HY-E70364 IgdE protease / 否
HY-RS02826 CLNK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CLNK VGNC VGNC:27454
Macaca mulatta CLNK VGNC VGNC:71196
Rattus norvegicus CLNK RGD RGD:1562417
Felis catus CLNK VGNC VGNC:60969
Mus musculus CLNK MGD MGI:1351468
Canis familiaris CLNK VGNC VGNC:39352
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z