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  2. Alox12 - arachidonate 12-lipoxygenase Gene

Alox12 - arachidonate 12-lipoxygenase Gene

中文名称:花生四烯酸 12-脂氧合酶

种属: Mus musculus

同用名: P-12LO; Alox12p; 9930022G08Rik

基因 ID: 11684 | 基因类型: protein coding

关于 Alox12

Chromosome 11: 70,132,283-70,146,179 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in genital fat pad adult (RPKM 9.9), spleen adult (RPKM 9.6) and 19 other tissues.


该基因编码的蛋白可启动花生四烯酸 12(S)-脂氧合酶活性和亚油酸 13S-脂氧合酶活性。参与建立皮肤屏障;脂肪酸代谢过程;和血小板聚集的负调节。位于细胞质中。在消化系统中表达;肝;肝左叶;和肝右叶。与人类 ALOX12(花生四烯酸 12-脂氧合酶,12S 型)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in establishment of skin barrier; fatty acid metabolic process; and negative regulation of platelet aggregation. Located in cytoplasm. Is expressed in alimentary system; liver; liver left lobe; and liver right lobe. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]

Alox12 基因产物(2)

mRNA Protein Name
NM_001331118.1 NP_001318047.1 polyunsaturated fatty acid lipoxygenase ALOX12 isoform 2
NM_007440.5 NP_031466.2 polyunsaturated fatty acid lipoxygenase ALOX12 isoform 1

Alox12 蛋白结构


PLAT_LOX: cd01753 (1 - 110)


Lipoxygenase: cl37981 (220 - 653)

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  • 663 a.a.
蛋白主名 其他名称

polyunsaturated fatty acid lipoxygenase ALOX12



arachidonate (12S)-lipoxygenase

arachidonate (15S)-lipoxygenase

arachidonate 12-lipoxygenase, 12S-type

arachidonate 15-lipoxygenase,15S-type

linoleate 13S-lipoxygenase

lipoxin synthase 12-LO

platelet-type lipoxygenase 12


种属 基因名 来源 基因 ID
Homo sapiens Alox12 NCBI NCBI:239