Birc2 - baculoviral IAP repeat-containing 2 Gene

中文名称：含杆状病毒 IAP 重复 2

种属: Mus musculus

同用名: Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc3; HIAP1; HIAP2; MIAP1; MIAP2; RNF48; cIAP1; cIAP2; C-IAP1; mcIAP1; C330006D17Rik

关于 Birc2

功能概要

预计该基因编码的蛋白可启动多种功能，包括 FBXO 家族蛋白结合活性；伴侣结合活动；和参与细胞凋亡过程的半胱氨酸型内肽酶抑制剂活性。参与坏死过程。作用于多个过程的上游或内部，包括对肿瘤坏死因子的细胞反应；坏死过程的负调控；和参与坏死过程的 ripoptosome 组装的负调节。位于质膜的细胞质侧。 CD40 受体复合体的一部分。表达于脑室层；泌尿生殖系统；和胸腺原基。该基因的人类直系同源物与乳腺癌有关。与人类 BIRC2 同源（杆状病毒 IAP 重复包含 2）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in necroptotic process. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; negative regulation of necroptotic process; and negative regulation of ripoptosome assembly involved in necroptotic process. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in brain ventricular layer; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]