2. Gene
  3. EXOSC6 - exosome component 6 Gene

EXOSC6 - exosome component 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外泌体组分 6

种属: Homo sapiens

同用名: p11; EAP4; MTR3; Mtr3p; hMtr3p

基因 ID: 118460 | 基因类型: protein coding

关于 EXOSC6

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,246,778-70,251,940 (from NCBI)

This gene has 1 transcript (splice variant), 155 orthologues and 2 paralogues.

功能概要

该基因产物构成称为外泌体的多亚基颗粒的亚基之一，它介导 mRNA 降解。人类外泌体的组成与其酵母对应物相似。该蛋白与酵母 Mtr3 蛋白同源。它的确切功能尚不清楚，但是，使用无细胞 RNA 衰变系统表明，外泌体是快速降解含有富含 AU 元素 (ARE) 的不稳定 mRNA 所必需的，而不是 poly (A) 缩短所必需的。外泌体本身不能识别含有 ARE 的 mRNA，但需要 ARE 结合蛋白，这些蛋白可以与外泌体相互作用并将其募集到不稳定的 mRNA，从而促进它们的快速降解。[RefSeq 提供，2008 年 7 月]

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]

EXOSC6 基因产物(1)

mRNA Protein Name
NM_058219.3 NP_478126.1 exosome complex component MTR3

EXOSC6 蛋白结构

RNase_PH

RNase_PH: 3' exoribonuclease family, domain 1 (36 - 175)

  • 0
  • 100
  • 200
  • 272 a.a.
蛋白主名 其他名称

exosome complex component MTR3

Mtr3 (mRNA transport regulator 3)-homolog

关联疾病

疾病名称 别名
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b

PCH1B

Pontocerebellar Hypoplasia 1b

Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia, Type 1c

PCH1C

Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

Pontocerebellar Hypoplasia Type 1c

Pontocerebellar Hypoplasia 1c

Doid:0112334

Hypoplasia, Pontocerebellar, Type 1c
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Trichohepatoenteric Syndrome 2

THES2
Plantar Wart

Verruca Plantaris

Verrucae On Sole Of Foot

Mosaic Plantar Warts
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04602 EXOSC6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus EXOSC6 RGD RGD:1309832
Bos taurus EXOSC6 VGNC VGNC:106728
Mus musculus EXOSC6 MGD MGI:1919794
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z