Bak1 - BCL2-antagonist/killer 1 Gene

中文名称：BCL2-拮抗因子/杀手 1

种属: Mus musculus

同用名: Bak; N-Bak; N-BAK1

关于 Bak1

功能概要

实现相同的蛋白质结合活性。参与细胞对紫外线的反应和线粒体中细胞色素 c 的释放。作用于多个过程的上游或内部，包括凋亡信号通路；细胞钙离子稳态；和淋巴细胞凋亡过程。位于胞质溶胶中；内质网；和线粒体膜。是线粒体外膜的组成部分。 Bak 复合体的一部分。以多种结构表达，包括消化系统；脑;鳃弓;泌尿生殖系统；和淋巴系统腺体。该基因的人类直系同源物与共济失调毛细血管扩张症和宫颈癌有关。与人类 BAK1（BCL2 拮抗剂/杀手 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Involved in cellular response to UV and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; cellular calcium ion homeostasis; and lymphocyte apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial membrane. Is integral component of mitochondrial outer membrane. Part of Bak complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]