1. Gene
  2. Bcl2l1 - BCL2-like 1 Gene

Bcl2l1 - BCL2-like 1 Gene

中文名称:BCL2 样1

种属: Mus musculus

同用名: BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1

基因 ID: 12048 | 基因类型: protein coding

关于 Bcl2l1

Chromosome 2: 152,622,588-152,673,648 reverse strand.GRCm39:CM000995.3

This gene has 9 transcripts (splice variants), 285 orthologues, 10 paralogues and is associated with 20 phenotypes. Ubiquitous expression in thymus adult (RPKM 18.5), liver E14.5 (RPKM 15.3) and 28 other tissues.


该基因编码凋亡调节剂 Bcl-2 家族的成员。编码的蛋白质定位于线粒体内膜和外膜,并在发育和组织稳态过程中调节程序性细胞死亡途径。这种蛋白质与线粒体外膜中的电压依赖性阴离子通道结合,以促进钙离子的摄取。缺乏该基因的小鼠胚胎存活了两周,并表现出未成熟的造血细胞和神经元的细胞死亡。可变剪接导致多个转录本变体。已经描述了该基因的其他可变剪接转录变体,但它们的全长性质尚不清楚。 [RefSeq 提供,2014 年 1 月]

This gene encodes a member of the Bcl-2 Family of Apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]

Bcl2l1 基因产物(5)

mRNA Protein Name
NM_001289717.1 NP_001276646.1 bcl-2-like protein 1 isoform a
NM_001289739.1 NP_001276668.1 bcl-2-like protein 1 isoform b
NM_001355053.1 NP_001341982.1 bcl-2-like protein 1 isoform a
NM_009743.5 NP_033873.3 bcl-2-like protein 1 isoform a
NM_001289716.1 NP_001276645.1 bcl-2-like protein 1 isoform a

Bcl2l1 蛋白结构


bcl-2: TIGR00865 (0 - 232)

  • 0
  • 100
  • 200
  • 233 a.a.
蛋白主名 其他名称

bcl-2-like protein 1

B-cell leukemia/lymphoma x

anti-apoptosis regulatory protein

apoptosis regulator Bcl-X

重组 Bcl2l1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72846 Bcl-XL Protein, Mouse (His) Q64373-1 (M1-R212) ≥95%


种属 基因名 来源 基因 ID
Homo sapiens Bcl2l1 NCBI NCBI:598