1. Gene
  2. ACSM2A - acyl-CoA synthetase medium chain family member 2A Gene

ACSM2A - acyl-CoA synthetase medium chain family member 2A Gene

中文名称:酰基辅酶 A 合成酶中链家族成员 2A

种属: Homo sapiens

同用名: ACSM2; A-923A4.1

基因 ID: 123876 | 基因类型: protein coding

关于 ACSM2A

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,451,521-20,487,669 (from NCBI)

This gene has 16 transcripts (splice variants), 254 orthologues and 13 paralogues. Restricted expression toward kidney (RPKM 83.2).

功能概要

该基因编码线粒体酰基辅酶 A 合成酶,该酶对中链脂肪酸具有特异性。这些酶通过酰基辅酶 A 的转移催化脂肪酸活化,这是脂肪酸代谢的第一步。这些酶还参与苯甲酸盐和布洛芬等异生素解毒过程中的甘氨酸结合途径。该基因在肾脏中的表达水平可能与肾功能相关。该基因及其旁系同源物 ACSM2B (基因 ID:348158) 均存在于 16 号染色体上,可能源于染色体复制事件。[RefSeq 提供,2017 年 5 月]

This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017]

ACSM2A 基因产物(3)

mRNA Protein Name
NM_001308169.2 NP_001295098.1 acyl-coenzyme A synthetase ACSM2A, mitochondrial isoform 2
NM_001308172.2 NP_001295101.1 acyl-coenzyme A synthetase ACSM2A, mitochondrial isoform 1
NM_001308954.2 NP_001295883.1 acyl-coenzyme A synthetase ACSM2A, mitochondrial isoform 1

ACSM2A 蛋白结构

AMP-binding

AMP-binding: AMP-binding enzyme (66 - 468)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (477 - 557)

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  • 577 a.a.
蛋白主名 其他名称

acyl-coenzyme A synthetase ACSM2A, mitochondrial

acyl-CoA synthetase medium-chain family member 2

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ACSM2A RGD RGD:708383
Mus musculus ACSM2A MGD MGI:2385289