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  2. Cckar - cholecystokinin A receptor Gene

Cckar - cholecystokinin A receptor Gene

中文名称:胆囊收缩素A受体

种属: Mus musculus

基因 ID: 12425 | 基因类型: protein coding

关于 Cckar

Chromosome 5: 53,855,118-53,865,047 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 202 orthologues, 16 paralogues and is associated with 21 phenotypes. Biased expression in lung adult (RPKM 14.7), kidney adult (RPKM 12.1) and 4 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动胆囊收缩素受体活性和肽激素结合活性。作用于轴突发生的上游或内部;前脑发育;和神经元迁移。预计位于多个细胞成分中,包括核内体;溶酶体;和终端按钮。预计是质膜的组成部分。以多种结构表达,包括大脑;泌尿生殖系统;直觉;和呼吸系统。该基因的人类直系同源物与肥胖有关。与人 CCKAR(胆囊收缩素 A 受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable Cholecystokinin Receptor activity and peptide hormone binding activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Predicted to be located in several cellular components, including endosome; lysosome; and terminal bouton. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]

Cckar 基因产物(2)

mRNA Protein Name
NM_009827.2 NP_033957.1 cholecystokinin receptor type A isoform 1
NM_001347354.1 NP_001334283.1 cholecystokinin receptor type A isoform 2

Cckar 蛋白结构

CholecysA-Rec_N

CholecysA-Rec_N: pfam09193 (0 - 46)

7tm_GPCRs

7tm_GPCRs: cl28897 (41 - 388)

7tm_GPCRs

7tm_GPCRs: cd14964 (43 - 67)

7tm_GPCRs

7tm_GPCRs: cd14964 (76 - 98)

7tm_GPCRs

7tm_GPCRs: cd14964 (114 - 136)

7tm_GPCRs

7tm_GPCRs: cd14964 (159 - 175)

7tm_GPCRs

7tm_GPCRs: cd14964 (206 - 229)

7tm_GPCRs

7tm_GPCRs: cd14964 (319 - 341)

7tm_GPCRs

7tm_GPCRs: cd14964 (356 - 381)

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  • 436 a.a.
蛋白主名 其他名称

cholecystokinin receptor type A

CCK-A receptor

CCK-AR

CCK1-R

cholecystokinin-1 receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cckar NCBI NCBI:886