Ctss - cathepsin S Gene

中文名称：组织蛋白酶 S

种属: Mus musculus

同用名: Cats

关于 Ctss

功能概要

该基因编码半胱氨酸蛋白酶肽酶 C1（木瓜蛋白酶）家族的成员。可变剪接导致多个转录变体，这些变体编码前原蛋白，这些前原蛋白经过蛋白水解处理以产生成熟的蛋白质产物。这种酶在炎症期间由抗原呈递细胞分泌，可通过激活 G 蛋白偶联受体引起疼痛和瘙痒。该基因的纯合基因敲除小鼠表现出伤口愈合受损、胰腺癌模型中的肿瘤发生减少以及重症肌无力模型中的发病机制减少。 [RefSeq 提供，2015 年 8 月]

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This Enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic Cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]