NACC2 - NACC family member 2 Gene

中文名称：NACC 家族成员 2

种属: Homo sapiens

同用名: RBB; BEND9; NAC-2; BTBD14; BTBD31; BTBD14A

关于 NACC2

功能概要

启用多种功能，包括 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性；组蛋白脱乙酰酶结合活性；和蛋白质同二聚化活性。参与多个过程，包括通过负调节 RNA 聚合酶 II 启动子的转录来负调节有丝分裂细胞周期的 G1/S 转换；响应 DNA 损伤的内在凋亡信号通路的正向调节；和蛋白质同源寡聚化。位于染色质；线粒体；和核仁。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Located in chromatin; mitochondrion; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]