2. Gene
  3. ADGRG4 - adhesion G protein-coupled receptor G4 Gene

ADGRG4 - adhesion G protein-coupled receptor G4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 G4

种属: Homo sapiens

同用名: PGR17; GPR112; RP1-299I16

基因 ID: 139378 | 基因类型: protein coding

关于 ADGRG4

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,300,963-136,416,890 (from NCBI)

This gene has 3 transcripts (splice variants), 68 orthologues and 42 paralogues. Biased expression in duodenum (RPKM 1.3), small intestine (RPKM 0.8) and 2 other tissues.

功能概要

该基因编码一个 G 蛋白偶联受体，属于参与各种生理功能的多种多样的整合膜蛋白大家族。这个超家族成员的特征是具有标志性的 7 跨膜结构域基序。该家族成员的配体未知，因此它是一个孤儿受体。已知该受体在正常肠嗜铬细胞和胃肠道神经内分泌癌细胞中表达，因此被认为是免疫治疗的新型生物标志物或靶标。[RefSeq 提供，2010 年 5 月]

This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]

ADGRG4 基因产物(1)

mRNA Protein Name
NM_153834.4 NP_722576.3 adhesion G-protein coupled receptor G4

ADGRG4 蛋白结构

Pentaxin

Pentaxin: Pentaxin family (41 - 210)

GPS

GPS: GPCR proteolysis site, GPS, motif (2683 - 2728)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (2743 - 2982)

  • 0
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  • 3080 a.a.
蛋白主名 其他名称

adhesion G-protein coupled receptor G4

G protein-coupled receptor 112

关联疾病

疾病名称 别名
Neuroendocrine Carcinoma

Neuroendocrine Cancer

Carcinoma Neuroendocrine

Carcinoma, Neuroendocrine
Martin-Probst Syndrome

Deafness-Intellectual Disability, Martin-Probst Type Syndrome

Martin-Probst Deafness-Mental Retardation Syndrome

Mental Retardation, X-Linked, Syndromic, Martin-Probst Type

MRXSMP

Deafness-Intellectual Disability Syndrome, Martin-Probst Type

Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type

X-Linked Deafness-Intellectual Disability Syndrome Syndrome

X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Spastic Diplegia

Diplegic Infantile Cerebral Palsy

Little'S Disease

Cerebral Palsy

Cerebral Spastic Infantile Paralysis

Infantile Diplegic Cerebral Palsy

Infantile Spastic Cerebral Palsy

Littles Disease

Spastic Cerebral Palsy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00357 ADGRG4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADGRG4 RGD RGD:1564057
Mus musculus ADGRG4 MGD MGI:2685213
Canis familiaris ADGRG4 VGNC VGNC:37646
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