1. Gene
  2. CRY1 - cryptochrome circadian regulator 1 Gene

CRY1 - cryptochrome circadian regulator 1 Gene

中文名称:隐花色素昼夜节律调节器 1

种属: Homo sapiens

同用名: DSPD; PHLL1

基因 ID: 1407 | 基因类型: protein coding

关于 CRY1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,991,364-107,093,549 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues.


该基因编码一种黄素腺嘌呤二核苷酸结合蛋白,它是调节生物钟的昼夜节律核心振荡器复合体的关键组成部分。该基因被 CLOCK/ARNTL 异二聚体上调,但随后使用 PER/CRY 异二聚体与 CLOCK/ARNTL 相互作用在反馈回路中抑制这种上调。该基因的多态性与睡眠模式的改变有关。编码的蛋白质在植物和动物中广泛保存。小鼠相关基因的缺失导致完全黑暗中的昼夜节律周期缩短。[RefSeq 提供,2014 年 1 月]

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

CRY1 基因产物(14)

mRNA Protein Name
NM_001413458.1 NP_001400387.1 cryptochrome-1 isoform a
NM_001413459.1 NP_001400388.1 cryptochrome-1 isoform b
NM_001413460.1 NP_001400389.1 cryptochrome-1 isoform c
NM_001413461.1 NP_001400390.1 cryptochrome-1 isoform d
NM_001413462.1 NP_001400391.1 cryptochrome-1 isoform d
NM_001413463.1 NP_001400392.1 cryptochrome-1 isoform e
NM_001413464.1 NP_001400393.1 cryptochrome-1 isoform f
NM_001413465.1 NP_001400394.1 cryptochrome-1 isoform f
NM_001413466.1 NP_001400395.1 cryptochrome-1 isoform g
NM_001413467.1 NP_001400396.1 cryptochrome-1 isoform h
NM_001413468.1 NP_001400397.1 cryptochrome-1 isoform h
NM_001413469.1 NP_001400398.1 cryptochrome-1 isoform h
NM_001413470.1 NP_001400399.1 cryptochrome-1 isoform h
NM_004075.5 NP_004066.1 cryptochrome-1 isoform d

CRY1 蛋白结构


DNA_photolyase: DNA photolyase (5 - 159)


FAD_binding_7: FAD binding domain of DNA photolyase (212 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 586 a.a.
蛋白主名 其他名称


cryptochrome 1 (photolyase-like)


疾病名称 别名
Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To


Delayed Sleep Phase Disorder, Susceptibility To


Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Advanced Sleep Phase Syndrome


Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial

Sleep Apnea

Sleep Apnea Syndromes

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder


Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder



Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression



Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode


Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern



Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Apnea, Obstructive Sleep

Obstructive Sleep Apnea Syndrome

Obstructive Sleep Apnea

Sleep Apnea, Obstructive



Sleep Apnea/Hypopnea Syndrome


Upper Airway Resistance Sleep Apnea Syndrome

Apnea, Obstructive

Obstructive Apnea


Sleep Apnea Hypopnea Syndrome

Sleep Apnea Syndrome, Obstructive

Sleep Apnea Obstructive

Sleep Apnea Syndromes

Obstructive Sleep Apnoea Syndrome

Obstructive Sleep Apnoea, Adult

Osa - [Obstructive Sleep Apnoea]

Obstructive Sleep Apnoea, Paediatric

Obstructive Sleep Apnoea Hypopnoea Syndrome

Osa Syndrome

Sleep Apnoea Nos

[Sas] - Sleep Apnoea Syndrome

Sleep Apnoea Syndrome

[Osahs] - Obstructive Sleep Apnoea-Hypopnea Syndrome

[Sahs] - Sleep Apnoea-Hypopnea Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Macaca mulatta CRY1 VGNC VGNC:71499
Bos taurus CRY1 VGNC VGNC:27730
Felis catus CRY1 VGNC VGNC:61195
Canis familiaris CRY1 VGNC VGNC:39633
Mus musculus CRY1 MGD MGI:1270841
Rattus norvegicus CRY1 RGD RGD:735083