1. Gene
  2. BCDIN3D - BCDIN3 domain containing RNA methyltransferase Gene

BCDIN3D - BCDIN3 domain containing RNA methyltransferase Gene

中文名称:含 BCDIN3 结构域的 RNA 甲基转移酶

种属: Homo sapiens

基因 ID: 144233 | 基因类型: protein coding


Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,836,043-49,843,106 (from NCBI)

This gene has 2 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 3.3), lymph node (RPKM 3.0) and 25 other tissues.


该基因编码属于 rossmann 折叠甲基转移酶家族的 RNA 甲基转移酶,作为 5'-甲基磷酸加帽酶,对细胞质组氨酰 tRNA 具有特异性。编码的蛋白质包含一个 S-腺苷甲硫氨酸结合域,并使用甲基供体 S-腺苷甲硫氨酸。该基因在乳腺癌细胞中过表达,与乳腺癌的致瘤表型和不良预后有关。编码的蛋白质被认为通过相应前体 miRNA 的 5-单磷酸酯的二甲基化下调肿瘤抑制 miRNA 的表达,从而促进乳腺癌细胞的细胞侵袭。[RefSeq 提供,2017 年 4 月]

This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping Enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast Cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast Cancer. The encoded protein is thought to promote the cellular invasion of breast Cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]

BCDIN3D 基因产物(1)

mRNA Protein Name
NM_181708.3 NP_859059.1 RNA 5'-monophosphate methyltransferase

BCDIN3D 蛋白结构


Bin3: Bicoid-interacting protein 3 (Bin3) (158 - 212)

  • 0
  • 100
  • 200
  • 292 a.a.
蛋白主名 其他名称

RNA 5'-monophosphate methyltransferase

BCDIN3 domain containing RNA methyltransfease


疾病名称 别名
Malignant Essential Hypertension

Accelerated Essential Hypertension

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast


Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Bos taurus BCDIN3D VGNC VGNC:26442
Mus musculus BCDIN3D MGD MGI:1922534
Canis familiaris BCDIN3D VGNC VGNC:38404
Macaca mulatta BCDIN3D VGNC VGNC:70137
Rattus norvegicus BCDIN3D RGD RGD:1306433
Felis catus BCDIN3D VGNC VGNC:60081