1. Gene
  2. VCAN - versican Gene

VCAN - versican Gene

中文名称:万能的

种属: Homo sapiens

同用名: WGN; ERVR; GHAP; PG-M; WGN1; CSPG2

基因 ID: 1462 | 基因类型: protein coding

关于 VCAN

Cytogenetic location: 5q14.2-q14.3 Genomic coordinates (GRCh38): 5:83,471,744-83,582,302 (from NCBI)

This gene has 12 transcripts (splice variants), 320 orthologues, 7 paralogues and is associated with 3 phenotypes. Broad expression in appendix (RPKM 45.0), placenta (RPKM 35.3) and 15 other tissues.

功能概要

该基因是聚集蛋白聚糖/多功能聚糖蛋白聚糖家族的成员。编码的蛋白质是一种大的硫酸软骨素蛋白多糖,是细胞外基质的主要成分。该蛋白参与细胞粘附、增殖、增殖、迁移和血管生成,并在组织形态发生和维持中起着核心作用。该基因的突变是 1 型瓦格纳综合征的原因。已发现该基因编码不同亚型的多个转录变体。[RefSeq 提供,2009 年 8 月]

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

VCAN 基因产物(4)

mRNA Protein Name
NM_001126336.3 NP_001119808.1 versican core protein isoform 2 precursor
NM_001164097.2 NP_001157569.1 versican core protein isoform 3 precursor
NM_001164098.2 NP_001157570.1 versican core protein isoform 4 precursor
NM_004385.5 NP_004376.2 versican core protein isoform 1 precursor

VCAN 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (28 - 140)

Xlink

Xlink: Extracellular link domain (149 - 244)

Xlink

Xlink: Extracellular link domain (250 - 346)

EGF

EGF: EGF-like domain (3093 - 3122)

EGF

EGF: EGF-like domain (3131 - 3159)

Lectin_C

Lectin_C: Lectin C-type domain (3187 - 3291)

Sushi

Sushi: Sushi repeat (SCR repeat) (3296 - 3352)

  • 0
  • 600
  • 1200
  • 1800
  • 2400
  • 3000
  • 3396 a.a.
蛋白主名 其他名称

versican core protein

chondroitin sulfate proteoglycan core protein 2

重组 VCAN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79125 Versican Isoform V3 Protein, Human (CHO, His) P13611-4 (L21-Y646) ≥95%

关联疾病

疾病名称 别名
Wagner Vitreoretinopathy

Hyaloideoretinal Degeneration Of Wagner

Wagner Syndrome

Wagner Vitreoretinal Degeneration

Erosive Vitreoretinopathy

Ervr

Wagner Syndrome 1

Wgn1

Wagner Disease

WGVRP

Vcan-Related Vitreoretinopathy

Wagner Syndrome Type 1

Dominant Hyaloideoretinal Dystrophy Of Wagner

Vitreoretinal Degeneration, Wagner Type

Wagner'S Disease

Vcan-Related Vitreoretinopathy

Hyaloideoretinal Degeneration Of Wagner

Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal

Pneumonic Plague

Primary Pneumonic Plague

Secondary Pneumonic Plague

Plague

Plague, Pneumonic

Plague Pneumonia

Plague Of Lung

Pulmonary Plague

Pneumonia Due To Yersinia Pestis

Vitreoretinopathy
Septicemic Plague

Plague, Septicemic

Bubonic Plague

Black Death

Plague, Bubonic

Plague, Septicemic

Pestis Bubonica

Aortic Aneurysm

Aortic Rupture

Thoracoabdominal Aortic Aneurysm, Ruptured

Ruptured Aortic Aneurysm

Aortic Aneurysms

Aortic Aneurysm Without Mention Of Rupture Nos

Ruptured Abdominal Aortic Aneurysm

Aortic Aneurysm, Ruptured

Ruptured Thoracic Aortic Aneurysm

Vitreous Syneresis

Vitreous Degeneration

Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness

Telogen Effluvium
Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection

Aortic Valve Disease 1

Aortic Valve Disease

Bicuspid Aortic Valve

Aortic Valve Disorder

AOVD1

Bav

Bicuspid Aortic Valve Disease

Familial Bicuspid Aortic Valve

Aortic Valve Calcification

Aovd

Aortic Valve, Bicuspid

Aortic Valve, Calcification Of

Aortic Stenosis, Calcific

Familial Bav

Calcific Aortic Stenosis

Calcification Of Aortic Valve

Abnormality Of The Aortic Valve

Aortic Valve Disease, Type 1

Aortic Valve Disease 2

Bicommissural Aortic Valve

Stickler Syndrome

Arthroophthalmopathy

Hereditary Arthro-Ophthalmo-Dystrophy

Hereditary Arthro-Ophthalmopathy

Stickler Dysplasia

Hereditary Progressive Arthroophthalmopathy

Stickler Syndrome, Type 1

Orthostatic Intolerance

Mitral Valve Prolapse

Neurocirculatory Asthenia

Mitral Valve Prolapse Syndrome

Irritable Heart

Systolic Click-Murmur Syndrome

Soldiers Heart

Cardiovascular Malfunction Arising From Mental Factors

Cardiovascular Neurosis

Da Costa'S Syndrome

Krishaber'S Disease

Barlow'S Syndrome

Floppy Mitral Valve

Mitral Leaflet Syndrome

Myxomatous Mitral Valve Prolapse

Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency

Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency

Orthostatic Intolerance Due To Net Deficiency

Pots Due To Net Deficiency

OI

Intolerance, Orthostatic

Mitral Valve Prolapse, Familial, X-Linked

Ballooning Mitral Valve

Barlow Syndrome

Flail Mitral Leaflet

Myxomatous Mitral Valve

Mitral Valve Prolapse-Click Syndrome

Prolapsing Mitral Valve Leaflet Syndrome

Billowing Mitral Valve Leaflet

Posterior Mitral Leaflet Deformity

Ballooning Posterior Leaflet Syndrome

Blue Valve Syndrome

Floppy Mitral Valve Syndrome

Mitral Valvular Prolapse

Systolic Click Syndrome

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris VCAN VGNC VGNC:48241
Bos taurus VCAN VGNC VGNC:36778
Felis catus VCAN VGNC VGNC:66931
Mus musculus VCAN MGD MGI:102889
Rattus norvegicus VCAN RGD RGD:619940
Macaca mulatta VCAN VGNC VGNC:79445