2. Gene
  3. ADRA2A - adrenoceptor alpha 2A Gene

ADRA2A - adrenoceptor alpha 2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肾上腺素受体α2A

种属: Homo sapiens

同用名: ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR

基因 ID: 150 | 基因类型: protein coding

关于 ADRA2A

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:111,077,029-111,080,907 (from NCBI)

This gene has 1 transcript (splice variant), 230 orthologues and 18 paralogues.

功能概要

α-2-肾上腺素能受体是 G 蛋白偶联受体超家族的成员。 α-2-肾上腺素能受体是一种肾上腺素能受体 (用于肾上腺素或肾上腺素) ，可抑制腺苷酸环化酶。这些受体包括 3 种高度同源的亚型：alpha2A、alpha2B 和 alpha2C。它们参与调节交感神经和中枢神经系统肾上腺素能神经元的神经递质分子的释放。交感神经系统通过激活心脏、血管和肾脏中的肾上腺素能受体来调节心血管功能。对小鼠的研究表明，alpha2A 和 alpha2C 受体亚型是心脏交感神经系统和中枢去甲肾上腺素能神经元释放突触前递质所必需的。 α-2-肾上腺素能受体还通过细胞外调节蛋白激酶 1 和 2 (ERK1/2) 通路参与儿茶酚胺信号传导。尚未确定 α-2-肾上腺素能受体与疾病之间的明确关联。[RefSeq 提供，2019 年 9 月]

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit Adenylate Cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in Catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]

ADRA2A 基因产物(1)

mRNA Protein Name
NM_000681.4 NP_000672.3 alpha-2A adrenergic receptor

ADRA2A 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (65 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
蛋白主名 其他名称

alpha-2A adrenergic receptor

adrenergic, alpha-2A-, receptor

关联疾病

疾病名称 别名
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
Motion Sickness

Airsickness

Carsickness

Seasickness

Travel Sickness

Riders' Vertigo
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Oppositional Defiant Disorder

Disorder

Oppositional Defiance

Behavioural Disorder

Oppositional Defiance

Disruptive Mood Dysregulation Disorder
Constipation
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Mood Disorder

Mood Disorders

Episodic Mood Disorder
Specific Developmental Disorder
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N8728 Aposcopolamine 98.44% 否
HY-145700 UCSF648 / 否
HY-163694 ADRA2A antagonist 1 Antagonist / 否
HY-RS00411 ADRA2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ADRA2A VGNC VGNC:52983
Mus musculus ADRA2A MGD MGI:87934
Rattus norvegicus ADRA2A RGD RGD:2056
Macaca mulatta ADRA2A VGNC VGNC:100292
Bos taurus ADRA2A VGNC VGNC:106632
Others ADRA2A NCBI
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