DAD1 - defender against cell death 1 Gene

中文名称：细胞死亡防御者 1

种属: Homo sapiens

同用名: OST2

关于 DAD1

功能概要

DAD1 是防止细胞凋亡的防御者，最初被确定为温度敏感 tsBN7 细胞系中程序性细胞死亡的负调节因子。在转变为非允许温度后，DAD1 蛋白在温度敏感细胞中消失，这表明 DAD1 蛋白的丢失引发了细胞凋亡。 DAD1 被认为是完整膜和纯化酶中寡糖基转移酶的紧密相关亚基，因此反映了真核生物中 N-连接糖基化的基本性质。[RefSeq 提供，2008 年 7 月]

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered Apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified Enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]