AP1G1 - adaptor related protein complex 1 subunit gamma 1 Gene

中文名称：适配器相关蛋白复合物 1 亚基 γ 1

种属: Homo sapiens

同用名: ADTG; CLAPG1; USRISD

关于 AP1G1

功能概要

适应蛋白是网格蛋白包被的囊泡的重要组成部分，可将配体-受体复合物从质膜或跨高尔基体网络转运至溶酶体。适应蛋白家族由四类分子组成，分别称为α、β-、β-和γ-适应蛋白。适应蛋白与中、小亚基一起形成称为适配器的异四聚体复合物，其作用是促进网格蛋白包被的小坑和小泡的形成。该基因编码的蛋白质是一种γ-适应蛋白，属于衔接复合物大亚基家族。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]