1. Gene
  2. AGRP - agouti related neuropeptide Gene

AGRP - agouti related neuropeptide Gene


种属: Homo sapiens


基因 ID: 181 | 基因类型: protein coding


Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,482,571-67,483,547 (from NCBI)

This gene has 1 transcript (splice variant), 179 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in adrenal (RPKM 1.6), lung (RPKM 0.8) and 5 other tissues.


该基因编码黑皮质素 3 和黑皮质素 4 受体的拮抗剂。它似乎通过黑皮质素受体和/或细胞内钙调节来调节下丘脑对进食行为的控制,因此在体重稳态中发挥作用。该基因的突变与迟发性肥胖有关。[RefSeq 提供,2009 年 12 月]

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via Melanocortin Receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

AGRP 基因产物(1)

mRNA Protein Name
NM_001138.2 NP_001129.1 agouti-related protein precursor

AGRP 蛋白结构


Agouti: Agouti protein (33 - 122)

  • 0
  • 100
  • 132 a.a.
蛋白主名 其他名称

agouti-related protein

agouti related protein homolog

重组 AGRP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75526 AGRP Protein, Human (HEK293, His) O00253 (A21-T132) ≥95%
HY-P75527 AGRP Protein, Human (48a.a, HEK293, Fc) O00253 (S85-T132) ≥95%
HY-P75528 AGRP Protein, Human (HEK293, Fc) O00253 (A21-T132) ≥95%


疾病名称 别名
Body Mass Index Quantitative Trait Locus 11


Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To


Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified


Anorexia Nervosa

Anorexia Nervosa, Susceptibility To


Anorexia Nervosa, Susceptibility To, 1


Anorexia Nervosa 1

An - [Anorexia Nervosa]

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome


Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome


Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency


Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency


Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Acquired Metabolic Disease
Type 2 Diabetes Mellitus

Insulin Resistance


Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent


Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes


Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]


Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Rattus norvegicus AGRP RGD RGD:2068
Macaca mulatta AGRP VGNC VGNC:104680
Bos taurus AGRP VGNC VGNC:25743
Mus musculus AGRP MGD MGI:892013
Canis familiaris AGRP VGNC VGNC:37717