1. Gene
  2. Nos3 - nitric oxide synthase 3, endothelial cell Gene

Nos3 - nitric oxide synthase 3, endothelial cell Gene

中文名称:一氧化氮合酶 3 ,内皮细胞

种属: Mus musculus

同用名: eNOS; Nos-3; ecNOS; 2310065A03Rik

基因 ID: 18127 | 基因类型: protein coding

关于 Nos3

Chromosome 5: 24,569,808-24,589,472 forward strand.GRCm39:CM000998.3

This gene has 2 transcripts (splice variants), 114 orthologues, 5 paralogues and is associated with 243 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 22.), mammary gland adult (RPKM 2.1) and 26 other tissues.


该基因编码的蛋白可启动一氧化氮合酶活性和支架蛋白结合活性。参与多个过程,包括心脏发育;肌肉增生的负调节;和平滑肌增生。作用于多个过程的上游或内部,包括脂多糖介导的信号通路;一氧化氮生物合成过程;和调节金属离子传输。位于细胞质和细胞核中。以多种结构表达,包括消化系统;心血管系统;泌尿生殖系统;淋巴系统腺体;和神经系统。用于研究主动脉瓣疾病;原发性高血压;和持续性胎儿循环综合征。该基因的人类直系同源物与多种疾病有关,包括阿尔茨海默病(多种);动脉疾病(多发性);眼病(多发);生殖器官癌(多发性);和血管炎(多发性)。与人 NOS3(一氧化氮合酶 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including heart development; negative regulation of muscle hyperplasia; and smooth muscle hyperplasia. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; nitric oxide biosynthetic process; and regulation of metal ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study aortic valve disease; essential hypertension; and persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ Cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Apr 2022]

Nos3 基因产物(1)

mRNA Protein Name
NM_008713.4 NP_032739.3 nitric oxide synthase, endothelial

Nos3 蛋白结构


NOS_oxygenase_euk: cd00795 (66 - 478)


Flavodoxin_1: pfam00258 (520 - 696)


FNR_like: cl06868 (760 - 1162)

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  • 1202 a.a.
蛋白主名 其他名称

nitric oxide synthase, endothelial


NOS type III



constitutive NOS

endothelial NOS

endothelial nitric oxide synthase


种属 基因名 来源 基因 ID
Homo sapiens Nos3 NCBI NCBI:4846