Nos3 - nitric oxide synthase 3, endothelial cell Gene

中文名称：一氧化氮合酶 3 ，内皮细胞

种属: Mus musculus

同用名: eNOS; Nos-3; ecNOS; 2310065A03Rik

关于 Nos3

功能概要

该基因编码的蛋白可启动一氧化氮合酶活性和支架蛋白结合活性。参与多个过程，包括心脏发育；肌肉增生的负调节；和平滑肌增生。作用于多个过程的上游或内部，包括脂多糖介导的信号通路；一氧化氮生物合成过程；和调节金属离子传输。位于细胞质和细胞核中。以多种结构表达，包括消化系统；心血管系统;泌尿生殖系统；淋巴系统腺体；和神经系统。用于研究主动脉瓣疾病；原发性高血压;和持续性胎儿循环综合征。该基因的人类直系同源物与多种疾病有关，包括阿尔茨海默病（多种）；动脉疾病（多发性）；眼病（多发）；生殖器官癌（多发性）；和血管炎（多发性）。与人 NOS3（一氧化氮合酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including heart development; negative regulation of muscle hyperplasia; and smooth muscle hyperplasia. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; nitric oxide biosynthetic process; and regulation of metal ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study aortic valve disease; essential hypertension; and persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ Cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Apr 2022]