2. Gene
  3. DTX1 - deltex E3 ubiquitin ligase 1 Gene

DTX1 - deltex E3 ubiquitin ligase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：deltex E3 泛素连接酶 1

种属: Homo sapiens

同用名: hDx-1; RNF140

基因 ID: 1840 | 基因类型: protein coding

关于 DTX1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,056,730-113,098,025 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 13.1), spleen (RPKM 9.7) and 18 other tissues.

功能概要

在果蝇中的研究已经确定该基因编码 Notch 信号通路的正调节因子。人类基因编码一种功能未知的蛋白质；然而，它可能在基本的螺旋-环-螺旋转录因子活性中发挥作用。[RefSeq 提供，2008 年 7 月]

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

DTX1 基因产物(1)

mRNA Protein Name
NM_004416.3 NP_004407.2 E3 ubiquitin-protein ligase DTX1

DTX1 蛋白结构

WWE

WWE: WWE domain (23 - 94)

WWE

WWE: WWE domain (101 - 171)

zf-RING_2

zf-RING_2: Ring finger domain (410 - 472)

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  • 620 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase DTX1

RING-type E3 ubiquitin transferase DTX1

关联疾病

疾病名称 别名
Familial Pityriasis Rubra Pilaris

Familial Prp

Pityriasis Rubra Pilaris--Familial Type
Pityriasis Rubra Pilaris

PRP

Devergie'S Disease

Prp - [Pityriasis Rubra Pilaris]
N1 Diffuse Large B-Cell Lymphoma

N1 Dlbcl

Doid:0081067
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126931 Dinophysistoxin 1 / 否
HY-RS04038 DTX1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DTX1 RGD RGD:1585380
Felis catus DTX1 VGNC VGNC:61648
Macaca mulatta DTX1 VGNC VGNC:108340
Mus musculus DTX1 MGD MGI:1352744
Bos taurus DTX1 VGNC VGNC:28236
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