1. Gene
  2. Rela - v-rel reticuloendotheliosis viral oncogene homolog A (avian) Gene

Rela - v-rel reticuloendotheliosis viral oncogene homolog A (avian) Gene

中文名称:v-rel 网状内皮增生病毒致癌基因同系物 A (鸟类)

种属: Mus musculus

同用名: p65; p65 NFkB; p65 NF-kappa B

基因 ID: 19697 | 基因类型: protein coding

关于 Rela

Chromosome 19: 5,687,511-5,698,158 forward strand.GRCm39:CM001012.3

This gene has 7 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 47 phenotypes. Ubiquitous expression in adrenal adult (RPKM 78.1), lung adult (RPKM 46.5) and 28 other tissues.


该基因编码的蛋白可启动多种功能,包括 DNA 结合转录因子活性、RNA 聚合酶 II 特异性;肌动蛋白结合活性;和锚蛋白重复结合活性。涉及多个过程,包括蛋白质苏木化的负调节;突触后核信号通路;和转录调控,DNA 模板化。在几个过程的上游或内部起作用,包括对肝细胞生长因子刺激的细胞反应;细胞对脂多糖的反应;白介素 12 生成的正向调节。位于几种细胞成分中,包括染色质;胞质溶胶;和谷氨酸能突触。以多种结构表达,包括消化系统;早孕;泌尿生殖系统;肌肉组织;和皮肤。该基因的人类直系同源物与原位导管癌有关;肺非小细胞癌;淋巴瘤;和肾细胞癌。与人类 RELA 同源(RELA 原癌基因,NF-kB 亚基)。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; postsynapse to nucleus signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to lipopolysaccharide; and positive regulation of interleukin-12 production. Located in several cellular components, including chromatin; cytosol; and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rela 基因产物(3)

mRNA Protein Name
NM_001402548.1 NP_001389477.1 transcription factor p65 isoform p65 iso 3
NM_009045.5 NP_033071.1 transcription factor p65 isoform 1
NM_001365067.1 NP_001351996.1 transcription factor p65 isoform 2

Rela 蛋白结构


RHD-n_RelA: cd07885 (18 - 186)


IPT_NFkappaB: cd01177 (193 - 289)


PHA03247: cl33720 (254 - 520)

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  • 549 a.a.
蛋白主名 其他名称

transcription factor p65

avian reticuloendotheliosis viral (v-rel) oncogene homolog A

nuclear factor NF-kappa-B p65 subunit

nuclear factor of kappa light polypeptide gene enhancer in B-cells 3


种属 基因名 来源 基因 ID
Homo sapiens Rela NCBI NCBI:5970
Canis familiaris Rela NCBI NCBI:483729
Macaca fascicularis Rela NCBI NCBI:101867324
Canis lupus familiaris Rela NCBI
Rattus norvegicus Rela NCBI NCBI:309165
Macaca mulatta Rela NCBI NCBI:715919