Rela - v-rel reticuloendotheliosis viral oncogene homolog A (avian) Gene

中文名称：v-rel 网状内皮增生病毒致癌基因同系物 A (鸟类)

种属: Mus musculus

同用名: p65; p65 NFkB; p65 NF-kappa B

关于 Rela

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录因子活性、RNA 聚合酶 II 特异性；肌动蛋白结合活性；和锚蛋白重复结合活性。涉及多个过程，包括蛋白质苏木化的负调节；突触后核信号通路；和转录调控，DNA 模板化。在几个过程的上游或内部起作用，包括对肝细胞生长因子刺激的细胞反应；细胞对脂多糖的反应；白介素 12 生成的正向调节。位于几种细胞成分中，包括染色质；胞质溶胶；和谷氨酸能突触。以多种结构表达，包括消化系统；早孕;泌尿生殖系统；肌肉组织；和皮肤。该基因的人类直系同源物与原位导管癌有关；肺非小细胞癌；淋巴瘤;和肾细胞癌。与人类 RELA 同源（RELA 原癌基因，NF-kB 亚基）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; postsynapse to nucleus signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to lipopolysaccharide; and positive regulation of interleukin-12 production. Located in several cellular components, including chromatin; cytosol; and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]