1. Gene
  2. CADM4 - cell adhesion molecule 4 Gene

CADM4 - cell adhesion molecule 4 Gene

中文名称:细胞粘附分子 4

种属: Homo sapiens

同用名: NECL4; TSLL2; IGSF4C; Necl-4; synCAM4

基因 ID: 199731 | 基因类型: protein coding

关于 CADM4

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,622,368-43,641,984 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 14 paralogues. Biased expression in brain (RPKM 59.7), kidney (RPKM 14.7) and 8 other tissues.


启用血管内皮生长因子受体 2 结合活性。参与多个过程,包括蛋白质磷酸化的负调节;调节 Rac 蛋白信号转导;和伤口愈合的调节。位于细胞前缘和细胞间接触区。 [由基因组资源联盟提供,2022 年 4 月]

Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Apr 2022]

CADM4 基因产物(1)

mRNA Protein Name
NM_145296.2 NP_660339.1 cell adhesion molecule 4 precursor

CADM4 蛋白结构


V-set: Immunoglobulin V-set domain (28 - 117)


C2-set_2: CD80-like C2-set immunoglobulin domain (130 - 206)


Ig_2: Immunoglobulin domain (228 - 302)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

cell adhesion molecule 4

TSLC1-like 2

重组 CADM4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76187 CADM4/IGSF4C Protein, Human (HEK293, His) Q8NFZ8 (M1-Y323) ≥95%
HY-P76188 CADM4/IGSF4C Protein, Human (HEK293, Fc) Q8NFZ8 (M1-Y323) ≥95%


疾病名称 别名
Ciliary Dyskinesia, Primary, 22

Primary Ciliary Dyskinesia 22


Primary Ciliary Dyskinesia 22 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 22, With Or Without Situs Inversus

Dyskinesia, Ciliary, Primary, 22

Spondylometaphyseal Dysplasia With Cone-Rod Dystrophy

Spondylometaphyseal Dysplasia-Cone-Rod Dystrophy Syndrome



Dysplasia, Spondylometaphyseal, With Cone-Rod Dystrophy

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4

Charcot-Marie-Tooth Disease Type 4e

Hereditary Motor And Sensory Neuropathy



Hypomyelinating Neuropathy, Congenital, 1

Charcot-Marie-Tooth Neuropathy Type 4e

Neuropathy, Congenital Hypomyelinating, 1


Autosomal Recessive Demyelinating Charcot-Marie-Tooth


Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

Hypomyelination, Severe Congenital

Charcot-Marie-Tooth Disease, Type 4e

Charcot-Marie-Tooth Neuropathy, Type 4e

Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

Autosomal Recessive Congenital Hypomyelinating Neuropathy

Congenital Amyelinating Neuropathy

Congenital Hypomyelinating Neuropathy Autosomal Recessive

Neuropathy, Congenital Hypomyelinating Or Amyelinating

Severe Congenital Hypomyelination

Hereditary Sensory Motor Neuropathy

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

Neuropathy, Hypomyelinating, Congenital, Type 1

Neuropathy, Motor And Sensory, Hereditary

Congenital Hypomyelinating Neuropathy

Hereditary Motor And Sensory Neuropathies

Hereditary Sensorimotor Neuropathy

Hmsn - [Hereditary Motor And Sensory Neuropathy]

Hsmn - [Hereditary Sensory And Motor Neuropathy]

Hereditary Motor And Sensory Neuropathy, Types I-Iv

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Canis familiaris CADM4 VGNC VGNC:53675
Mus musculus CADM4 MGD MGI:2449088
Macaca mulatta CADM4 VGNC VGNC:70681
Rattus norvegicus CADM4 RGD RGD:1304722
Bos taurus CADM4 VGNC VGNC:26697
Felis catus CADM4 VGNC VGNC:60315