Scn9a - sodium channel, voltage-gated, type IX, alpha Gene

中文名称：钠通道，电压门控， IX 型， α

种属: Mus musculus

同用名: PN1; Nav1.7; mKIAA4197

关于 Scn9a

功能概要

预测该基因编码的蛋白可启动钠离子结合活性和电压门控钠通道活性。在几个过程的上游或内部起作用，包括对疼痛的行为反应；炎症反应；和对有毒物质的反应。预计是质膜的组成部分。预计是电压门控钠通道复合体的一部分。预计在轴突中活跃。以多种结构表达，包括消化系统；脑;免疫系统;雄性生殖腺或器官；和呼吸系统上皮。该基因的人类直系同源物与红斑性肢痛有关；全身性癫痫伴热性惊厥加 7；和阵发性极度疼痛障碍。与人类 SCN9A（钠电压门控通道 α 亚基 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable sodium ion binding activity and voltage-gated Sodium Channel activity. Acts upstream of or within several processes, including behavioral response to pain; inflammatory response; and response to toxic substance. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated Sodium Channel complex. Predicted to be active in axon. Is expressed in several structures, including alimentary system; brain; immune system; male reproductive gland or organ; and respiratory system epithelium. Human ortholog(s) of this gene implicated in erythromelalgia; generalized epilepsy with febrile seizures plus 7; and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2022]