1. Gene
  2. TUBB - tubulin beta class I Gene

TUBB - tubulin beta class I Gene

中文名称:I 类微管蛋白

种属: Homo sapiens

同用名: M40; TUBB1; TUBB5; CDCBM6; CSCSC1; OK/SW-cl.56

基因 ID: 203068 | 基因类型: protein coding


Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,720,352-30,725,422 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 271 orthologues, 23 paralogues and is associated with 5 phenotypes. Ubiquitous expression in ovary (RPKM 250.9), bone marrow (RPKM 212.6) and 25 other tissues.


该基因编码 β 微管蛋白。这种蛋白质与 α 微管蛋白形成二聚体,并作为微管的结构成分。该基因的突变会导致复杂的皮质发育不良,并伴有其他大脑畸形 6。可变剪接导致多个剪接变体。该基因在 1、6、7、8、9 和 13 号染色体上有多个假基因。[RefSeq 提供,2014 年 6 月]

This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

TUBB 基因产物(6)

mRNA Protein Name
NM_001293212.2 NP_001280141.1 tubulin beta chain isoform a
NM_001293213.2 NP_001280142.1 tubulin beta chain isoform c
NM_001293214.2 NP_001280143.1 tubulin beta chain isoform d
NM_001293215.2 NP_001280144.1 tubulin beta chain isoform e
NM_001293216.2 NP_001280145.1 tubulin beta chain isoform e
NM_178014.4 NP_821133.1 tubulin beta chain isoform b

TUBB 蛋白结构


Tubulin: Tubulin/FtsZ family, GTPase domain (3 - 222)


Tubulin_C: Tubulin C-terminal domain (261 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
蛋白主名 其他名称

tubulin beta chain

beta Ib tubulin


疾病名称 别名
Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6



Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Skin Creases, Congenital Symmetric Circumferential, 1

Michelin Tire Baby Syndrome


Skin Creases, Multiple Benign Ring-Shaped, Of Limbs

Circumferential Skin Creases, Kunze Type

Congenital Symmetric Circumferential Skin Creases 1

Circumferential Skin Creases Kunze Type

Symmetric Circumferential Skin Creases, Congenital, 1


Multiple Benign Ring-Shaped Skin Creases Of Limbs

Michelin-Tire Baby

Multiple Benign Circumferential Skin Creases On Limbs


Circumferential Skin Creases, Kunze Type

Congenital Circumferential Skin Folds

Kunze-Riehm Syndrome

Kunze Riehm Syndrome

Michelin Tire Baby Syndrome

Tubulin, Beta


Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum


Hydrocephalus, Congenital, 1



Hydrocephalus, Nonsyndromic, Autosomal Recessive 1


Congenital Non-Communicating Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly

Congenital Obstructive Hydrocephalus

Hydrocephalus, Non-Syndromic, Autosomal Recessive 1


Skin Creases, Congenital Symmetric Circumferential, 2


Symmetric Circumferential Skin Creases, Congenital, 2

Congenital Symmetric Circumferential Skin Creases 2

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British


Presenile Dementia With Spastic Ataxia

Familial British Dementia

Abri Amyloidosis

Cerebral Amyloid Angiopathy, British Type

Itm2b-Related Cerebral Amyloid Angiopathy 1

Familial Dementia, British Type

Cerebral Amyloid Angiopathy, Itm2b-Related 1


Cerebral Amyloid Angiopathy British Type

Dementia, Familial, British

Charcot-Marie-Tooth Disease, Axonal, Type 2k

Charcot-Marie-Tooth Disease Axonal Type 2k


Autosomal Recessive Charcot-Marie-Tooth Disease With Hoarseness


Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2k

Autosomal Recessive Axonal Cmt4c4

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2k

Charcot-Marie-Tooth Neuropathy, Axonal, Type 2k

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2k

Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Disease Type 2k

Charcot-Marie-Tooth Neuropathy Axonal Type 2k

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2k

Charcot-Marie-Tooth Disease 2k

Charcot-Marie-Tooth Disease Neuronal Type 2k

Charcot-Marie-Tooth Neuropathy Type 2k

Charcot-Marie-Tooth Disease, Type 2k

Cerebellar Hypoplasia





Childhood Ganglioglioma

Adult Ganglioglioma

Cns Ganglioglioma

Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor


Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer


Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma


Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma






Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain



Axonal Neuropathy

Medullary Cystic Disease

Medullary Cystic Kidney



Kidney Disease, Cystic, Medullary

Neurofibromatosis-Noonan Syndrome


Neurofibromatosis Type 1

Neurofibromatosis With Noonan Phenotype


Von Recklinghausen Disease

Neurofibromatosis Type 1-Noonan Syndrome

Noonan Neurofibromatosis Syndrome

Recklinghausen'S Disease

Noonan-Neurofibromatosis Syndrome

Fibromatosis Multiple Non Ossifying

Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots

Jaffe Campanacci Syndrome

Type 1 Neurofibromatosis

Neurofibromatosis 1

Peripheral Neurofibromatosis

Recklinghausen Disease, Nerve

Jaffe-Campanacci Syndrome

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma



Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles



Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon


Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast


Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis


Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease


Amyotrophic Lateral Sclerosis, Susceptibility To


Lou Gehrig'S Disease


Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Felis catus TUBB VGNC VGNC:66699
Canis familiaris TUBB VGNC VGNC:110552
Bos taurus TUBB VGNC VGNC:103058
Rattus norvegicus TUBB RGD RGD:628596
Macaca mulatta TUBB VGNC VGNC:104438
Mus musculus TUBB MGD MGI:107812