2. Gene
  3. Gcgr - glucagon receptor Gene

Gcgr - glucagon receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：胰高血糖素受体

种属: Rattus norvegicus

基因 ID: 24953 | 基因类型: protein coding

关于 Gcgr

Primary_assembly 10: 105,808,473-105,816,640 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 184 orthologues, 42 paralogues and is associated with 4 phenotypes. Biased expression in Liver (RPKM 26.9), Kidney (RPKM 67.8) and 5 other tissues.

功能概要

该基因编码的蛋白可启动胰高血糖素受体活性和肽激素结合活性。参与腺苷酸环化酶激活G蛋白偶联受体信号通路；胞吐作用;和激素介导的信号通路。位于核内体和质膜。该基因的人类直系同源物与 Mahvash 病和 2 型糖尿病有关。与人类 GCGR（胰高血糖素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Glucagon Receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; exocytosis; and hormone-mediated signaling pathway. Located in endosome and plasma membrane. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (Glucagon Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gcgr 基因产物(2)

mRNA Protein Name
NM_172092.2 NP_742089.1 glucagon receptor precursor
NM_172091.2 NP_742088.1 glucagon receptor precursor

Gcgr 蛋白结构

HRM

HRM: pfam02793 (60 - 127)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (141 - 422)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (145 - 170)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (179 - 201)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (230 - 257)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (269 - 289)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (305 - 334)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (350 - 375)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (384 - 409)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
蛋白主名 其他名称

glucagon receptor

GL-R

glucagon receptor perhaps same as Niddm3

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13443 Exendin-4 Agonist 99.95% 是
HY-P0014 Liraglutide Agonist 99.85% 否
HY-P0082 Glucagon (1-29), bovine, human 99.91% 否
HY-P0120 Dulaglutide Agonist 99.20% 否
HY-13443A Exendin-4 acetate Agonist 99.91% 否
HY-P0082A Glucagon (1-29), bovine, human hydrochloride 99.89% 否
HY-P3469A Dasiglucagon acetate 98.66% 否
HY-P3469 Dasiglucagon Agonist / 否
Clinical Phase
生物活性分子 (19)
目录号 产品名 作用方式
纯度 Phase
HY-P3463 Beinaglutide 98.49% Phase 4
HY-112185 Orforglipron Agonist 99.64% Phase 3
HY-P4146 Survodutide Agonist 99.92% Phase 3
HY-P2221B Glepaglutide acetate Agonist 99.92% Phase 3
HY-P0165 Taspoglutide Agonist 99.43% Phase 3
HY-P4146A Survodutide TFA Agonist 99.39% Phase 3
HY-P2221 Glepaglutide Agonist 99.53% Phase 3
HY-P3375A Mazdutide TFA Agonist 99.27% Phase 3
HY-112668B Retagliptin hydrochloride / Phase 3
HY-P3506B Retatrutide acetate Agonist / Phase 3
HY-125824 Danuglipron Agonist 99.85% Phase 2
HY-50663 MK 0893 Antagonist 99.86% Phase 2
HY-19904 Adomeglivant Antagonist 99.63% Phase 2
HY-12525 LGD-6972 Antagonist 98.0% Phase 2
HY-19947 PF-06291874 Antagonist 99.31% Phase 2
HY-P10018 Bamadutide Agonist 99.96% Phase 2
HY-P3498 Elsiglutide Agonist 99.64% Phase 2
HY-P10031 SAR441255 Agonist 99.77% Phase 1
HY-19374 BAY-27-9955 Antagonist / Phase 1
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99383 Volagidemab Antagonist ≥99.0% Phase 2
HY-P99357 Crotedumab Inhibitor 96.61% Phase 1
Pre-clinical Phase
生物活性分子 (144)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P3506 Retatrutide Agonist 99.96% 否
HY-P0055 GLP-1(7-37) 99.89% 否
HY-P0054 GLP-1(7-36), amide acetate 99.36% 否
HY-121835 GLP-1R agonist 2 Agonist 99.94% 否
HY-P3375 Mazdutide Agonist 99.94% 否
HY-103546 BETP Agonist 99.48% 否
HY-P1141 GLP-1(9-36)amide Antagonist 99.69% 否
HY-101116 GLP-1R Antagonist 1 Antagonist 99.67% 否
HY-P3506A Retatrutide TFA Agonist 99.10% 否
HY-P0055A GLP-1(7-37) acetate 99.59% 否
HY-P1024 GLP-2(1-33)(human) Agonist 98.24% 否
HY-P2231A Cotadutide acetate Agonist 98.99% 否
HY-P0054B GLP-1(7-36), amide TFA 98.59% 否
HY-10930 UNC0321 Inhibitor 99.91% 否
HY-129658A TT-OAD2 Agonist 99.77% 否
HY-124622 NNC-0640 Modulator 98.43% 否
HY-142162 LSN3318839 Modulator 99.81% 否
HY-P10736A AMG133 peptide payload TFA Agonist 99.70% 否
HY-P3291 Dapiglutide Agonist 99.40% 否
HY-P1023 VIP(6-28)(human, rat, porcine, bovine) Antagonist 99.69% 否
HY-P1160 Bay 55-9837 Agonist 99.56% 否
HY-P0054A GLP-1(7-36), amide Agonist 99.90% 否
HY-P1144 Oxyntomodulin (bovine, porcine) Agonist 99.27% 否
HY-P2231 Cotadutide Agonist 99.11% 否
HY-P2625 GLP-2(3-33) Agonist 99.82% 否
HY-P3101 GLP-1(28-36)amide 98.64% 否
HY-112185A Orforglipron hemicalcium hydrate Agonist 99.71% 否
HY-P1145A Glucagon-like peptide 1 (1-37), human TFA Agonist 95.95% 否
HY-P0150 Glucagon (19-29), human Inhibitor 99.11% 否
HY-P3366 Ecnoglutide Agonist 99.90% 否
HY-N0630 Shanzhiside methyl ester Agonist 99.71% 否
HY-P0014S1 Liraglutide-13C5,15N TFA Agonist 98.19% 否
HY-P1348 GLP-1 moiety from Dulaglutide 99.59% 否
HY-103547 L-168049 Antagonist 99.94% 否
HY-P1143A [Des-His1,Glu9]-Glucagon amide TFA Antagonist 98.36% 否
HY-141842 GLP-1R modulator L7-028 Modulator 98.77% 否
HY-50159 Glucagon receptor antagonist-3 Antagonist 99.78% 否
HY-141840 GLP-1R modulator C5 Modulator 99.60% 否
HY-112679 GLP-1 receptor agonist 2 Agonist 98.18% 否
HY-116819 VU0453379 Modulator 98.0% 否
HY-141839 GLP-1R modulator C16 Modulator 99.60% 否
HY-P3102 GLP-1(32-36)amide 98.44% 否
HY-P1141A GLP-1(9-36)amide TFA Antagonist 98.00% 否
HY-P10736 AMG133 peptide payload 95.57% 否
HY-148212 GLP-1R agonist 17 Agonist 99.82% 否
HY-145458 GLP-1 receptor agonist 9 Agonist 99.70% 否
HY-148844 GCGR antagonist 2 Antagonist 99.76% 否
HY-50158 Glucagon receptor antagonist-2 Antagonist 99.23% 否
HY-P10032A NN1177 TFA Agonist 98.66% 否
HY-145412 GLP-1 receptor agonist 7 98.41% 否
HY-144035 GLP-1R agonist 4 Agonist 99.77% 否
HY-P10019 Pegsebrenatide Agonist 95.50% 否
HY-144034 GLP-1R agonist 3 Agonist 99.15% 否
HY-116854 NNC 92-1687 Antagonist 98.74% 否
HY-50675 GRA Ex-25 Inhibitor 99.07% 否
HY-P5815A GLP-1 (1-36) amide (human, rat) TFA 98.81% 否
HY-13443B Exendin-4-Lys-azide TFA Agonist 96.88% 否
HY-116819A VU0453379 hydrochloride Modulator 99.0% 否
HY-P3622 (Ser8)-GLP-1 (7-36) amide, human Agonist 99.10% 否
HY-13443F1 Exendin-4, Cy5 labeled TFA Agonist 95.16% 否
HY-P3617 Glucagon (22-29) Agonist 99.69% 否
HY-P2497 Exendin (5-39) Antagonist 99.43% 否
HY-10036 Glucagon receptor antagonist-1 Antagonist 98.65% 否
HY-P1228 HAEGTFT 98.81% 否
HY-119739 Skyrin Antagonist 97.0% 否
HY-124803 GPCR modulator-1 Modulator / 否
HY-P3491 Pegloxenatide Agonist 90.00% 否
HY-P1227 SDV-Exendin-3/4 95.96% 否
HY-P5074 GRPP (human) Agonist 98.94% 否
HY-145632A Pemvidutide TFA Antagonist 98.07% 否
HY-145632 Pemvidutide Agonist / 否
HY-P10341 ZP3022 Agonist 98.00% 否
HY-N2452 Cochinchinenin C Agonist / 否
HY-147622 GLP-1R agonist 9 Agonist / 否
HY-P1223 Exendin-3/4 (59-86) 98.19% 否
HY-P1224 HAEGTFTSDVS 98.62% 否
HY-P1229 FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 98.01% 否
HY-P5815 GLP-1 (1-36) amide (human, rat) 98.10% 否
HY-P1225 {Val1}-Exendin-3/4 99.45% 否
HY-108795B [Gly8]-GLP-1(7-37) acetate Agonist 99.11% 否
HY-P10032 NN1177 Agonist 99.77% 否
HY-P1226 HAEGTFTSD Agonist 98.48% 否
HY-P1231 GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 99.03% 否
HY-145458A GLP-1 receptor agonist 9 citrate Agonist / 否
HY-P11274 Zenagamtide Agonist / 否
HY-128781 Glucagon receptor antagonist-5 Antagonist / 否
HY-138996 GLP-1 receptor agonist 8 Agonist / 否
HY-172811 DA-302168S Agonist / 否
HY-129658 TT-OAD2 free base Agonist / 否
HY-159696A ISIS 449884 sodium Inhibitor / 否
HY-P11044 GEP12 Agonist / 否
HY-P3050 Helospectin II Inhibitor / 否
HY-P4503 (D-His1)-Exenatide Control / 否
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / 否
HY-P1160A Bay 55-9837 TFA / 否
HY-P5161 FC382K10W15 Agonist / 否
HY-P0211 [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Antagonist / 否
HY-13443S Exendin-4 (Leu-13C6,15N) TFA / 否
HY-P11237 Enicepatide Agonist / 否
HY-P3102A GLP-1(32-36)amide TFA / 否
HY-172836S GLP-1 receptor agonist 17-d3 Agonist / 否
HY-P3101A GLP-1(28-36)amide TFA / 否
HY-13443F Exendin 4, biotin labeled Agonist / 否
HY-P2625S1 GLP-2(3-33) (Leu-13C6,15N) TFA Agonist / 否
HY-P3621 Biotinyl-Glucagon (1-29), human, bovine, porcine / 否
HY-128103 Glucagon receptor antagonist-7 Antagonist / 否
HY-129656 GLP-1 receptor agonist 3 Agonist / 否
HY-P3616 Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide / 否
HY-144135 GLP-1R agonist 7 Agonist / 否
HY-144136 GLP-1R agonist 8 Agonist / 否
HY-P4843 Gastric Inhibitory Polypeptide (6-30) amide (human) / 否
HY-106559 Sorbinicate Inhibitor / 否
HY-P3388 Utreglutide Agonist 98.42% 否
HY-169707 GCGR antagonist 3 Antagonist / 否
HY-P3539 Exendin-4 (3-39) / 否
HY-144134 GLP-1R agonist 6 Agonist / 否
HY-P4672 (Met(O)27)-Glucagon (1-29) (human, rat, porcine) / 否
HY-P3053 Helospectin I / 否
HY-159696 ISIS 449884 Inhibitor / 否
HY-P4459 (Des-Gly2)-Exenatide Control / 否
HY-171851 GLP-1R agonist 32 Agonist / 否
HY-P1143 [Des-His1,Glu9]-Glucagon amide Antagonist / 否
HY-P5578A A8SGLP-1 TFA Agonist / 否
HY-P3608 [Des-His1,Glu9] Glucagon Antagonist / 否
HY-P5161A FC382K10W15 TFA Agonist / 否
HY-107129 MK-3577 Antagonist / 否
HY-P0212A Neuropeptide Y, porcine TFA / 否
HY-P1144A Oxyntomodulin (bovine, porcine) (TFA) Agonist / 否
HY-P0212 Neuropeptide Y, porcine Agonist / 否
HY-153476 GIP/GLP-1 dual receptor agonist-1 Agonist / 否
HY-P5578 A8SGLP-1 Agonist / 否
HY-144133 GLP-1R agonist 5 Agonist / 否
HY-144033 GLP-1R agonist 1 Agonist / 否
HY-129657 GLP-1 receptor agonist 4 Agonist / 否
HY-172673 GLP-1R agonist 31 Agonist / 否
HY-P10337 OXM-7 Agonist / 否
HY-P2880 PHI-27 (porcine) / 否
HY-12525A LGD-6972 sodium Antagonist / 否
HY-12735 SCH 900822 Antagonist / 否
HY-125824A Danuglipron tromethamine Agonist / 否
HY-118914 Glucagon receptor antagonist inactive control Control / 否
HY-142162A (S,R)-LSN3318839 Control / 否
HY-P1145 Glucagon-like peptide 1 (1-37), human Agonist 99.70% 否
HY-P1543 Exendin-3 Antagonist 98.31% 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990013 Gulgafafusp alfa Inhibitor 95.48% 否
HY-P991099 Anti-GLP1R Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gcgr NCBI NCBI:2642
Mus musculus Gcgr NCBI NCBI:14527
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