1. GPCR/G Protein
  2. Glucagon Receptor
  3. Exendin (5-39)

Exendin (5-39) 

目录号: HY-P2497
产品使用指南

Exendin (5-39) 是一种强效的胰高血糖素样肽 1 (GLP-1 receptor) 受体拮抗剂。Exendin (5-39) 改善 β-淀粉样蛋白沉积的大鼠的记忆障碍。

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Custom Peptide Synthesis

Exendin (5-39) Chemical Structure

Exendin (5-39) Chemical Structure

CAS No. : 196109-27-0

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Description

Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1].

IC50 & Target

IC50: GLP-1 receptor[1]

In Vivo

Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG[1].

Animal Model: Wistar rats (3 weeks old and 18 days pregnant)[1]
Dosage: 0.3 μg
Administration: Intracerebroventricular injection; 0.3 μg; once daily; 1-week
Result: Inhibited GLT-1 protein levels and inhibited long-term depression in rats.
Molecular Weight

3806.30

Formula

C₁₆₉H₂₆₂N₄₄O₅₄S

CAS No.

196109-27-0

Sequence Shortening

TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Exendin (5-39)Glucagon ReceptorGCGRGLP-1 receptorimpairmentdepressiondentate gyrusInhibitorinhibitorinhibit

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Exendin (5-39)
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HY-P2497
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