2. GPCR/G Protein Neuronal Signaling
  3. GPR119
  4. GSK-1292263 hydrochloride

GSK-1292263 (hydrochloride) 是一种具有口服活性的 GPR119 激动剂 (对人类与大鼠 GPR119 的 pEC50 分别为约 6.9 和 6.7 nM)。GSK-1292263 可用于 2 型糖尿病和血脂异常的研究。

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GSK-1292263 hydrochloride

GSK-1292263 hydrochloride Chemical Structure

CAS No. : 1032824-54-6

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GSK-1292263 hydrochloride 相关抗体

Top Publications Citing Use of Products

    GSK-1292263 hydrochloride purchased from MCE. Usage Cited in: FASEB J. 2016 Jan;30(1):324-35.  [Abstract]

    Treatment with 2 synthetic GPR119 agonists, MBX-2982 (MBX) and GSK1292263 (GSK), suppresses T090-induced SREBP-1 expression and mRNA levels of SREBP-1 target genes such as FAS, ACC, and SCD-1.

    GSK-1292263 hydrochloride purchased from MCE. Usage Cited in: College of Pharmacy. Seoul National University. 2015 Aug.

    Effects of GPR119 ligands on T090-induced pSREBP-1 and lipogenic enzymes expression. Primary cultured hepatocytes from GPR119-WT and -KO mice and HepG2 cells are pretreated with two GPR119 ligands [(MBX (MBX-2982) or GSK (GSK1292263)] for 30 min and the cells are exposed to T090 for 12 h.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    GSK-1292263 (hydrochloride) is an orally active GPR119 agonist (pEC50 of approximately 6.9 and 6.7 nM for human and rat GPR119, respectively). GSK-1292263 is used in the research of type 2 diabetes and dyslipidemia[1].

    分子量

    493.02

    Formula

    C23H29ClN4O4S
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    GSK-1292263 hydrochloride 相关分类

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    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GSK-12922631032824-54-6GSK1292263GSK 1292263GPR119G Protein-Coupled Receptor 119type 2 diabetesdyslipidemiaInhibitorinhibitorinhibit

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    目录号：
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