2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Bacterial
  4. GSK945237

GSK945237 是一种强效且口服有效的细菌 IIA 型拓扑异构酶 (type IIA topoisomerases) 抑制剂。GSK945237 对革兰氏阳性菌和革兰氏阴性菌均具有广谱活性 (对流感嗜血杆菌 DNA 回旋酶的 IC50 为 0.034 μg/mL)。GSK945237 在大鼠呼吸道感染模型中显示出良好的体内抑菌活性。GSK945237 可用于抗感染研究。

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GSK945237

GSK945237 Chemical Structure

CAS No. : 944406-54-6

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GSK945237 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK945237 is a potent and orally active bacterial type IIA topoisomerases inhibitor. GSK945237 shows broad-spectrum activity against Gram-positive and Gram-negative bacteria (IC50 of 0.034 μg/mL against H. influenzae DNA gyrase). GSK945237 demonstrates good in vivo efficacy in a rat respiratory tract infection model. GSK945237 can be used for anti-infection research[1].

体外研究
(In Vitro)

GSK945237 (18-24 小时) 对流感嗜血杆菌、金黄色葡萄球菌和肺炎链球菌表现出抗菌活性，其 MIC 分别为 1、0.06 和 0.25 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK945237 相关抗体:
体内研究
(In Vivo)

GSK945237 (50 和 100 mg/kg，灌胃，每日两次，从感染后 1 小时开始，持续 2 天) 在由 quinolone 耐药性的肺炎链球菌 TPS3 引起的鼠呼吸道感染模型中，通过显著降低肺部细菌载量而展现出强效的体内抗菌活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats infected by the S. pneumoniae TPS3 (quinolone-resistant)[1]
Dosage: 50 and 100 mg/kg
Administration: i.g., b.i.d. for 2 days starting 1 h post infection
Result: Showed excellent efficacy at 50 and 100 mg/kg, with bacterial numbers reduced below the limit of detection in 3/5 and 5/5 animals, respectively.
分子量

451.49

Formula

C24H26FN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK945237 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK945237944406-54-6GSK 945237GSK-945237TopoisomeraseBacterialtype IIA topoisomerasesS. aureusS. pneumoniaeH. influenzaerat respiratory tract infection modelquinolone-resistantS. pneumoniae TPS3Inhibitorinhibitorinhibit

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