2. GPCR/G Protein
  3. GLP Receptor
  4. GUB021794

GUB021794 是一种利用 streaMLine 平台开发出来的一种强效的、高选择性的胰高血糖素样肽-1 受体 (GLP-1R) 激动剂，其 EC50 为 18 pM。GUB021794 对 SCTR 活性很弱，EC50 为 190 nM。GUB021794 在饮食诱导肥胖 (DIO) 小鼠模型中能显著降低小鼠体重，减少食物摄入和全身脂肪质量。GUB021794 可用于研究肥胖/糖尿病。

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Custom Peptide Synthesis

GUB021794

GUB021794 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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GUB021794 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC50 value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC50 value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes[1].

分子量

3862.38

Formula

C178H282N40O55
Sequence

His-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Tyr-Leu-{Lys(AEEA-γGlu-C20 diacid)}-Glu-Glu-Ala-{Aib}-Leu-Gln-Arg-Phe-Leu-Glu-His-Leu-Val-NH2
Sequence Shortening

H-{Aib}-EGTFTSDVSYL-{Lys(AEEA-γGlu-C20 diacid)}-EEA-{Aib}-LQRFLEHLV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GUB021794 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GUB021794GUB 021794GUB-021794GLP ReceptorMachine learningPeptide therapeuticsGLP-1 receptor agonistQuantitative structure-activity relationship (QSAR)Drug discovery platformInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P11262
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