1. Epigenetics TGF-beta/Smad Apoptosis
  2. PKC Apoptosis
  3. HBDDE

HBDDE,Ellagic acid 的衍生物,是一种同种型选择性 PKCαPKCγ 抑制剂,IC50 值分别为 43 μM 和 50 μM。HBDDE 对 PKCα/PKCγ 的选择性高于同工酶 PKCδ,PKCβI 和 PKCβII 。HBDDE 可诱导神经元凋亡 (apoptosis)。

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HBDDE Chemical Structure

HBDDE Chemical Structure

CAS No. : 154675-18-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].

IC50 & Target[1]

PKCα

43 μM (IC50)

PKCγ

50 μM (IC50)

体外研究
(In Vitro)

HBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Cerebellar granule cells
Concentration: 50 μM
Incubation Time: 5 hours
Result: Reduced cell viability significantly by ~70%.
分子量

338.31

Formula

C16H18O8

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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