2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis Bcl-2 Family CDK
  4. HDAC-IN-51

HDAC-IN-51 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂，对 HDAC10、HDAC1、HDAC2、 HDAC3 和 HDAC11 的 IC50 值分别为 0.32、0.353、0.431、0.515 和 85.4 μM。HDAC-IN-51 诱导细胞周期停滞和细胞凋亡，调节细胞周期/细胞凋亡相关的 miRNA 表达。HDAC-IN-51 可用于癌症研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HDAC-IN-51 Chemical Structure

HDAC-IN-51 Chemical Structure

CAS No. : 3026728-28-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HDAC-IN-51 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer[1].

IC50 & Target[1]

HDAC10

0.32 μM (IC50)

HDAC1

0.353 μM (IC50)

HDAC2

0.431 μM (IC50)

HDAC3

0.515 μM (IC50)

HDAC11

85.4 μM (IC50)

体外研究
(In Vitro)

HDAC-IN-51 (compound 8d; 1 nM-10 μM; 48 h) has antiproliferative activity with IC50 values of 0.54, 0.56, and 1.35 μM for K562, HCT116, and A549 cells, respectively[1].
HDAC-IN-51 (1 and 5 μM; 24 and 48 h; U937 leukaemia cells) arrests cell cycle at the G1 phase[1].
HDAC-IN-51 (1 and 5 μM; 48 h; U937 cells) induces apoptosis and down-regulates miRNAs with antiapoptotic activity (miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p,miR-21-5p)[1].
HDAC-IN-51 (1 and 5 μM; 48 h; U937 cells) increases mRNA expression of p21, BAX and BAK, down-regulates cyclin D1 and BCL-2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-51 相关抗体:

Cell Viability Assay[1]

Cell Line: K562, HCT116, and A549 cells
Concentration: 1 nM-10 μM
Incubation Time: 48 hours
Result: Inhibited cell growth in cancer cells.

Cell Cycle Analysis[1]

Cell Line: U937 leukaemia cells
Concentration: 1 and 5 μM
Incubation Time: 24 and 48 hours
Result: Blocked the cell cycle at the G1 phase in U937 leukaemia cells.

Western Blot Analysis[1]

Cell Line: U937 cells
Concentration: 1 and 5 μM
Incubation Time: 48 hours
Result: Down-regulates miRNAs with antiapoptotic activity including miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p,miR-21-5p.

Western Blot Analysis[1]

Cell Line: U937 cells
Concentration: 1 and 5 μM
Incubation Time: 48 hours
Result: Increased mRNA expression of p21, BAX and BAK and down-regulated cyclin D1 and BCL-2 in a dose-dependent manner.
分子量

436.51

Formula

C27H24N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-51 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-513026728-28-6HDACApoptosisBcl-2 FamilyCDKHistone deacetylasesCyclin dependent kinaseanticancercell cyclemiRNAsK562HCT116A549Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HDAC-IN-51
目录号：
HY-152173
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z