1. Neuronal Signaling Metabolic Enzyme/Protease
  2. Monoamine Oxidase COMT
  3. hMAO-B/MB-COMT-IN-2

hMAO-B/MB-COMT-IN-2 是一种双重的 MAO-B/MB-COMT 抑制剂 (IC50s: hMAO-B 为 2.5 μM,MB-COMT 为 3.84 μM)。hMAO-B/MB-COMT-IN-2 可保护细胞免受氧化损伤。hMAO-B/MB-COMT-IN-2 可用于帕金森病 (PD) 等神经退行性疾病的研究。

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hMAO-B/MB-COMT-IN-2 Chemical Structure

hMAO-B/MB-COMT-IN-2 Chemical Structure

CAS No. : 3033106-46-3

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查看 Monoamine Oxidase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC50s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD)[1].

体外研究
(In Vitro)

hMAO-B/MB-COMT-IN-2 (compound 8, 50 μM, 24 h) decreases in resazurin reduction in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-2 (50 μM, 24 h) displays lysosomal toxicity by producing ROS in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-2 (10 μM, 30 min) displays remarkable cytoprotective effects against t-BHP in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-2 is predicted to cross the blood-brain barrier (BBB) by passive diffusion, determined by the parallel artificial membrane permeability assay (PAMPA)-BBB kit[1].
hMAO-B/MB-COMT-IN-2 (30-50 μM, 24 h) has good safety profile in SK-N-SH cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

298.34

Formula

C17H18N2O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
hMAO-B/MB-COMT-IN-2
目录号:
HY-151390
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