2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Hsp90-IN-15

Hsp90-IN-15 是一种 Hsp90 抑制剂，显示出抗癌活性。Hsp90-IN-15 诱导细胞凋亡 (apoptosis)，阻滞 S 期细胞周期，并降低 Hela 细胞中 Hsp90 的表达水平。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Hsp90-IN-15 Chemical Structure

Hsp90-IN-15 Chemical Structure

CAS No. : 2252283-32-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Hsp90-IN-15 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hsp90-IN-15 is an Hsp90 inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of Hsp90 in Hela cell[1].

IC50 & Target

HSP90

 

体外研究
(In Vitro)

Hsp90-IN-15 (compound 22g) againsts HeLa, HepG2, and MDA-MB-23 cells with IC50s of 19.6 μM, 16.1 μM, and 22.1 μM, respectively[1].
Hsp90-IN-15 binds with Hsp90N, and the △Tm value is 10.92 °C[1].
Hsp90-IN-15 (0-20 μM; 48 h) arrests cell cycle at S phase in a dose-dependent manner[1].
Hsp90-IN-15 (0-20 μM; 48 h) exhibits an accumulation of early and late apoptotic cells in a time and dose dependent manner[1].
Caspase-3 is an executioner caspase and modifies apoptosis proteins[1].
Hsp90-IN-15 (0-50 μM; 48 h) increases the expression of Bax and cleaved-caspase 3, as well as downregulates the levels of Bcl-2, pro-caspase 3 and Hsp90[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hsp90-IN-15 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Arrested cell cycle at S phase dose-dependently.

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Induced apoptosis in HeLa cells.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 12.5, 25, 50 μM
Incubation Time: 48 hours
Result: Decreased the level of Hsp90 and increased the proportion of Bax/Bcl-2 as well.
分子量

416.48

Formula

C23H27F3N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hsp90-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hsp90-IN-152252283-32-0HSPHeat shock proteinsL-shaped matrine derivativesanticancer activitytargeted modificationMDA-MB-231HepG2HeLaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Hsp90-IN-15
目录号：
HY-150655
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z