2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel TRP Channel
  4. Hyperforin

Hyperforin  (Synonyms: 贯叶金丝桃素)

目录号: HY-116330
产品使用指南

摩尔计算器

Hyperforin 是瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin 通过激活 Ca2+ 传导非选择性典型 TRPC6 通道来调节 Ca2+ 水平。Hyperforin 还表现出多种药理活性，包括抗抑郁、抗肿瘤、抗痴呆、抗糖尿病等。Hyperforin 调节 γδ T 细胞分泌 IL-17α，改善 Imiquimod (HY-B0180) 诱导的银屑病样小鼠皮肤炎症。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Hyperforin dicyclohexylammonium salt 通常具有更好的水溶性和稳定性。

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Hyperforin Chemical Structure

Hyperforin Chemical Structure

CAS No. : 11079-53-1

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Hyperforin 的其他形式现货产品:

Customer Review

Other Forms of Hyperforin:

Hyperforin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model[1][2][3][4][5].

IC50 & Target

TRPC6[1]
体外研究
(In Vitro)

Hyperforin has a multi-directional mechanism of action. It blocks conductance of ligand-gated (GABA, NMDA, and AMPA receptors) and voltage-gated channels (Ca2+, K+, and Na+)[2].
Hyperforin (0.1, 1, 10 μM; 2 h) reduces the expression and secretion of IL-17A in γδ T cell in vitro cultured murine splenic γδ T cells[3].
Hyperforin (0.1, 1, 10 μM; 2 h) suppresses phosphorylation of MAPK and STAT3 pathways in TNF-α stimulated HaCaT cells[3].
Hyperforin (IC50=3.7 μmol/L) inhibits the microvascular tube formation and proliferation of HDMEC in a dose-dependent manner without toxic effects[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hyperforin 相关抗体:

Western Blot Analysis[3]

Cell Line: HaCaT cells
Concentration: 0.1, 1, 10 μM; with or without 10, 20 ng/mL TNF-α
Incubation Time: 2 hours
Result: Reduced the expressions of p-p38, p-ERK, p-JNK, and p-STAT3, especially at the dosage of 10 μM.
体内研究
(In Vivo)

Hyperforin (5 mg/kg; i.p.; once daily for 7 d) ameliorates Imiquimod (HY-B0180)-induced psoriatic skin lesion in mice, as well as inhibiting inflammatory cell infiltration and inflammatory cytokines release[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IMQ-induced psoriasis-like mice model[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; once daily for 7 days
Result: Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation.
Suppressed infiltration of CD3+ T cells and downregulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.
分子量

536.78

Formula

C35H52O4
CAS 号
中文名称

贯叶金丝桃素
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hyperforin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hyperforin11079-53-1贯叶金丝桃素Calcium ChannelTRP ChannelCa2+ channelsCa channelsTransient receptor potential channelsInhibitorinhibitorinhibit

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