1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. I-191

I-191 

目录号: HY-117793 纯度: 98.02%
产品使用指南

I-191 是一种有效选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。

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I-191 Chemical Structure

I-191 Chemical Structure

CAS No. : 1690172-25-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3850 In-stock
5 mg ¥3500 In-stock
10 mg ¥5500 In-stock
50 mg ¥16500 In-stock
100 mg ¥26500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

IC50 & Target

Protease-activated receptor 2[1]

In Vitro

I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells[1].

Molecular Weight

423.48

Formula

C₂₃H₂₆FN₅O₂

CAS No.

1690172-25-8

SMILES

O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3614 mL 11.8069 mL 23.6139 mL
5 mM 0.4723 mL 2.3614 mL 4.7228 mL
10 mM 0.2361 mL 1.1807 mL 2.3614 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

I-191I191I 191Protease-Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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产品名称:
I-191
目录号:
HY-117793
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