2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. I-BOP

I-BOP 是血栓素 A2 受体 (TP) 的激动剂，KD 为 0.61 nM。I-BOP 通过激活血管平滑肌中的 PI3K 通路来促进细胞增殖。I-BOP 剂量依赖性的双相影响海马神经元中的兴奋性突触后电位 (e.p.s.p.)。

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I-BOP Chemical Structure

I-BOP Chemical Structure

CAS No. : 128719-90-4

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I-BOP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle[1]. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons[2].

体外研究
(In Vitro)

I-BOP (1-100 nM) 激活 MAP 激酶，刺激酪氨酸磷酸化，从而激活 PI3K 信号通路[1]。
I-BOP (0.1-3 μM) 在低浓度时通过增加神经递质释放，增强海马 CA1 神经元的突触传递；在高浓度时通过降低膜输入阻力，抑制海马 CA1 神经元的兴奋性突触传递[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

I-BOP 相关抗体:

Western Blot Analysis[1]

Cell Line: A7r5.HEL.TP cell
Concentration: 1-100 nM
Incubation Time: 24 h
Result: Increased phosphorylated tyrosine.
分子量

512.38

Formula

C23H29IO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

I-BOP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

I-BOP128719-90-4Prostaglandin ReceptorA7r5CA1 neuronSprague-Dawley ratsInhibitorinhibitorinhibit

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