2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. ICI 89406

ICI 89406 是选择性的 β1 肾上腺素能受体 (β1 adrenergic receptor) 的拮抗剂，适用于 PET 用正电子发射器标记。

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ICI 89406 Chemical Structure

ICI 89406 Chemical Structure

CAS No. : 53671-71-9

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规格 价格 是否有货 数量
1 mg ￥1049
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ICI 89406 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET[1][2].

体内研究
(In Vivo)
Animal Model: Rats[2].
Dosage: 0.6, 5 or 50 mg/kg.
Administration: Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).
Result: Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.
分子量

354.40

Formula

C19H22N4O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

COA (188 KB)

产品使用指南 (1538 KB)
参考文献

ICI 89406 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI 8940653671-71-9ICI89406ICI-89406Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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产品名称：
ICI 89406
目录号：
HY-15726
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