2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Iloperidone hydrochloride

Iloperidone hydrochloride  (Synonyms: 盐酸伊潘立酮; HP 873 hydrochloride)

目录号: HY-17410A
产品使用指南

摩尔计算器

Iloperidone hydrochloride (HP 873 hydrochloride) 是一种 D2/5-HT2 受体拮抗剂，可作用于精神分裂症的非典型抗精神病药。

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Iloperidone hydrochloride Chemical Structure

Iloperidone hydrochloride Chemical Structure

CAS No. : 1299470-39-5

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Iloperidone hydrochloride 的其他形式现货产品:

Other Forms of Iloperidone hydrochloride:

Iloperidone hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iloperidone hydrochloride (HP 873 hydrochloride) is a D2/5-HT2 receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms[1][2].

IC50 & Target[1]

Rat D2 Receptor

54 nM (Ki)

Rat 5-HT2 Receptor

3.1 nM (Ki)

Rat D1 Receptor

546 nM (Ki)

Rat 5-HT1A Receptor

168 nM (Ki)

Rat 5-HT6 Receptor

42.7 nM (Ki)

Rat 5-HT7 Receptor

21.6 nM (Ki)

Human D1 Receptor

216 nM (Ki)

Human D3 Receptor

7.1 nM (Ki)

Human D4 Receptor

25 nM (Ki)

Human D5 Receptor

319 nM (Ki)

Human 5-HT2A Receptor

5.6 nM (Ki)

Human 5-HT2C Receptor

42.8 nM (Ki)

体外研究
(In Vitro)

Iloperidone hydrochloride displays higher affinity for the dopamine D3 receptor (Ki=7.1 nM) than for the dopamine D4 receptor (Ki=25 nM). Iloperidone displays high affinity for the 5-HT6 and 5-HT7 receptors (Ki=42.7 and 21.6 nM, respectively), and is found to have higher affinity for the 5-HT2A (Ki=5.6 nM) than for the 5-HT2C receptor (Ki=42.8 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iloperidone hydrochloride 相关抗体:
体内研究
(In Vivo)

Iloperidone hydrochloride is eliminated slowly, with a mean t1/2 of 13.5 to 14.0 hours. Coadministration with food did not significantly affect AUC, tmax, or Cmax. These results indicate that the rate of iloperidone's absorption is decreased, but the overall bioavailability is unchanged, when the drug is taken with food. Orthostatic hypotension, dizziness, and somnolence were the most commonly reported adverse events[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

462.94

Formula

C24H28ClFN2O4
CAS 号
中文名称

盐酸伊潘立酮；盐酸哌啶酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Iloperidone hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iloperidone1299470-39-5HP 873盐酸伊潘立酮盐酸哌啶酮HP873HP-8735-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorantipsychoticschizophreniasymptomsInhibitorinhibitorinhibit

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