2. Immunology/Inflammation Apoptosis Metabolic Enzyme/Protease MAPK/ERK Pathway NF-κB
  3. Toll-like Receptor (TLR) MDM-2/p53 MMP Caspase SOD p38 MAPK NF-κB Apoptosis
  4. Inotodiol

Inotodiol 激活 p53 信号通路，抑制 MMP-2/9，在 HeLa 癌细胞中表现出抗肿瘤活性。Inotodiol 抑制 ROS 的产生，并表现出抗氧化和神经保护作用。Inotodiol 抑制 MAPK 和 NF-κB 信号通路的激活，并表现出抗炎活性。Inotodiol 抑制 TLR-4 介导的 TNF-α 产生（在 BMMC 和 BMDM 中的 IC50 分别为 0.7 μM 和 3.0 μM），抑制肥大细胞脱颗粒，表现出抗过敏​​活性。Inotodiol 具有口服活性。

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Inotodiol

Inotodiol Chemical Structure

CAS No. : 35963-37-2

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5 mg ￥5400
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Inotodiol 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5].

体外研究
(In Vitro)

Inotodiol (0-100 μM, 72 h) 可抑制 HeLa 细胞增殖，抑制细胞迁移和侵袭，诱导 HeLa 细胞凋亡[2]。
Inotodiol (0.1-10 μM, 28 h) 可抑制活性氧 (ROS) 生成，激活超氧化物歧化酶 (SOD)，改善氧和葡萄糖缺乏引起的线粒体功能障碍，减少乳酸脱氢酶的泄露，并在 PC12 细胞中表现出神经保护作用[3]。
Inotodiol (2 μg/mL, 24 h) 可抑制 H2O2诱导的 IL-1β、IL-6、TNF-α 和 COX-2 表达，并阻断人真皮成纤维细胞 (HDF) 的衰老[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Inotodiol 相关抗体:

Cell Viability Assay[3]

Cell Line: PC12
Concentration: 0.1-10 μM
Incubation Time: 28 h
Result: Inproved the cell viability.

Apoptosis Analysis[2]

Cell Line: HeLa
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Induced apoptosis.

Western Blot Analysis[3]

Cell Line: HeLa
Concentration: 30-50 μM
Incubation Time: 48 h
Result: Upregulated the expression of p53, p21 and Bax, downregulated the expression of MMP-2/9, Bcl-2.

Cell Migration Assay [3]

Cell Line: HeLa
Concentration: 30-50 μM
Incubation Time: 48 h
Result: Inhibited cell migration.
体内研究
(In Vivo)

Inotodiol (2-20 mpk, po, once daily for 3-5 days) 可在小鼠被动全身过敏反应和被动皮肤过敏反应中抑制过敏反应，并表现出抗哮喘活性[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse passive anaphylaxis models[5]
Dosage: 2-20 mpk
Administration: po, once daily for 3-5 days
Result: Reduced the decrease in body temperature and ear swelling.
分子量

442.72

Formula

C30H50O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Inonotus obliquus Chaga
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Inotodiol 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inotodiol35963-37-2Toll-like Receptor (TLR)MDM-2/p53MMPCaspaseSODp38 MAPKNF-κBApoptosisMatrix metalloproteinasesSuperoxide DismutaseNuclear factor-κBNuclear factor-kappaBlanostane-typetriterpenoidsclerotiaInonotus obliquusanti-tumorcarcinogenesisInhibitorinhibitorinhibit

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