2. Metabolic Enzyme/Protease
  3. Amine N-methyltransferase
  4. JBSNF-000028

JBSNF-00002 是一种口服有效的三环类烟酰胺 N-甲基转移酶 (NNMT) 小分子抑制剂，其对人源、小鼠源和猴源的 NNMT 的 IC50 分别为 33、210、190 nM。JBSNF-00002 可在 U2OS 骨肉瘤细胞中降低内源性 MNA 水平，其 EC50 为 2.5 μM。JBSNF-00002 在饮食诱导肥胖 (DIO) 模型中表现出显著的抗肥胖和抗糖尿病活性。JBSNF-00002 可用于研究肥胖、2 型糖尿病及非酒精性脂肪肝等代谢疾病。

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JBSNF-000028

JBSNF-000028 Chemical Structure

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JBSNF-000028 的其他形式现货产品:

Customer Review

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JBSNF-000028 相关抗体

Top Publications Citing Use of Products

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NNMT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JBSNF-00002 is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease[1].
IC50 & Target[1]

NNMT

33 nM (IC50)

分子量

268.15

Formula

C11H14BrN3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JBSNF-000028 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBSNF-000028JBSNF000028JBSNF 000028Amine N-methyltransferasenicotinamide N-methyltransferase (NNMT) inhibitortricyclic compoundmetabolic disordersstructure-activity relationshippharmacokineticsdiet-induced obesityglucose toleranceMNA reductionco-crystal structureInhibitorinhibitorinhibit

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目录号：
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