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  4. JBSNF-000028 TFA

JBSNF-000028 TFA 

目录号: HY-151500A 纯度: 99.47%
COA 产品使用指南

摩尔计算器

JBSNF-000028 TFA 是一种具有口服活性的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂，对人 NNMT (hNNMT)、猴 NNMT (mkNNMT) 和小鼠 NNMT (mNNMT) 的 IC50 分别为 0.033 μM、0.19 μM 和 0.21 μM。

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JBSNF-000028 TFA Chemical Structure

JBSNF-000028 TFA Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1636
In-stock
5 mg ￥3600
In-stock
10 mg ￥5700
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of JBSNF-000028 TFA:

JBSNF-000028 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JBSNF-000028 TFA is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 TFA can be used for the research of metabolic disorders[1].

IC50 & Target

IC50: 0.033 μM (hNNMT), 0.19 μM (mkNNMT), 0.21 μM (mNNMT)[1]
体外研究
(In Vitro)

JBSNF-000028 TFA (24 h) inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells[1].
JBSNF-000028 TFA (10-100 μM; 72 h) has no cytotoxicity against HepG2 cells[1].
JBSNF-000028 TFA binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain)[1].
JBSNF-000028 TFA is inactive against a broad panel of targets related to metabolism and safety[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JBSNF-000028 TFA 相关抗体:
体内研究
(In Vivo)

JBSNF-000028 TFA (50 mg/kg; p.o.; twice daily for 27 days) improves glucose and lipid handling in mice with diet-induced obesity (DIO)[1].
JBSNF-000028 TFA (50 mg/kg; p.o.; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

301.26

Formula

C13H14F3N3O2
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 100 mg/mL (331.94 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3194 mL 16.5970 mL 33.1939 mL
5 mM 0.6639 mL 3.3194 mL 6.6388 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

JBSNF-000028 TFA 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3194 mL 16.5970 mL 33.1939 mL 82.9848 mL
5 mM 0.6639 mL 3.3194 mL 6.6388 mL 16.5970 mL
10 mM 0.3319 mL 1.6597 mL 3.3194 mL 8.2985 mL
15 mM 0.2213 mL 1.1065 mL 2.2129 mL 5.5323 mL
20 mM 0.1660 mL 0.8298 mL 1.6597 mL 4.1492 mL
25 mM 0.1328 mL 0.6639 mL 1.3278 mL 3.3194 mL
30 mM 0.1106 mL 0.5532 mL 1.1065 mL 2.7662 mL
40 mM 0.0830 mL 0.4149 mL 0.8298 mL 2.0746 mL
50 mM 0.0664 mL 0.3319 mL 0.6639 mL 1.6597 mL
60 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3831 mL
80 mM 0.0415 mL 0.2075 mL 0.4149 mL 1.0373 mL
100 mM 0.0332 mL 0.1660 mL 0.3319 mL 0.8298 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBSNF-000028JBSNF000028JBSNF 000028Otherstype 2 diabetesliver diseasesnicotinamide N-methyltransferaseNNMTInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151500A
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