2. MAPK/ERK Pathway
  3. JNK
  4. JNK3 inhibitor-8

JNK3 inhibitor-8 是一种有效的、选择性的，具有口服活性并可穿过血脑屏障的 JNK3 抑制剂，对 JNK3、JNK2、JNK1 的 IC50 值分别为 21, 2203, >10000 nM。JNK3 inhibitor-8 显示出显着的神经保护作用。JNK3 inhibitor-8 具有研究阿尔茨海默病 (AD) 的潜力。

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JNK3 inhibitor-8 Chemical Structure

JNK3 inhibitor-8 Chemical Structure

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JNK3 inhibitor-8 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK3 inhibitor-8 is a potent, delective, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 21, 2203, >10000 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-8 shows significant neuroprotective effects. JNK3 inhibitor-8 has the potential for the research of Alzheimer’s disease (AD)[1].

IC50 & Target[1]

JNK3

21 nM (IC50)

JNK2

2203 nM (IC50)

JNK1

>10000 nM (IC50)

体外研究
(In Vitro)

JNK3 inhibitor-8 (compound 3h; 10, 20 µM; 24, 48 h) 增加用 10 μM amyloid-β1-42处理的原代大鼠皮层神经元细胞活力[1]。
JNK3 inhibitor-8 (10, 20 µM) 降低 p-c-jun (S63)、p-c-jun (S73)、PARP 和 p-Tau 的表达当用10 μM 的 amyloid-β1-42 处理时[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3 inhibitor-8 相关抗体:

Cell Viability Assay[1]

Cell Line: primary rat cortex neuron cells
Concentration: 10, 20 µM
Incubation Time: 24, 48 h
Result: Increased cell viability when treatment with 10 μM amyloid-β1-42.

Western Blot Analysis[1]

Cell Line: primary rat cortex neuron cells
Concentration: 10, 20 µM
Incubation Time:
Result: Decreased the expression of p-c-jun (S63) and p-c-jun (S73) in 0.5 μM anisomycin or 10 μM amyloid-β1-42 stitumed, and decreased the expression of PARP and p-Tau expression when treatment with 10 μM amyloid-β1-42.
体内研究
(In Vivo)

JNK3 inhibitor-8 (30、60 mg/kg；口服；每日一次，持续 4 周) 对小鼠显示出显着的神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 month-old APP/PS1 AD mice[1]
Dosage: 30, 60 mg/kg
Administration: P.o.; daily for 4 weeks
Result: Decrease in escape time and distance traveled, showed a significantly higher level of altered behavioral ability compared to APP/PS1 and vehicle control in the Y-maze test, improved memory and cognitive function.
Animal Model: 10 month-old 3xTg AD mice[1]
Dosage: 30, 60 mg/kg
Administration: P.o.; daily for 4 weeks
Result: Decreased the escape time and the distance, increased TSPQ and TSTZ levels, significantly decreased the expression of pTau levels and improved memory and cognitive function.
分子量

579.62

Formula

C32H30FN7O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK3 inhibitor-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3 inhibitor-8JNKc-Jun N-terminal kinaseorally activecross the blood-brain barrierAlzheimer’s diseaseneuroprotectiveInhibitorinhibitorinhibit

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