KLD-12 TFA 

KLD-12 TFA is the TFA salt form of KLD-12 (HY-P2263). KLD-12 TFA is a self a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 TFA combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 TFA hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair^[1][2][3].

KLD-12 TFA 与 SDF-1 形成自组装多肽，提高骨髓基质细胞 (BMSC) 的存活率，通过 Wnt/β-catenin 通路促进 BMSC 成骨分化和细胞迁移^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KLD-12 TFA (10-250 μg/rat，单剂量，骨折部位注射) 在股骨钻孔损伤的 Sprague-Dawley 大鼠模型中，剂量依赖地促进骨折部位的骨再生^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1467.79 (free base)

C₆₈H₁₂₂N₁₆O₁₉.xC₂HF₃O₂

固体

Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2

Ac-KLDLKLDLKLDL-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs via the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858.   [Content Brief]

  [2]. Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103.   [Content Brief]

  [3]. Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001.  [Content Brief]