2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Lactandrate

Lactandrate 是一种 D-高氮杂-雄甾酮烷化剂。Lactandrate 可以与雌激素受体-α (ERα) 的配体结合域 (LBD) 发生相互作用。Lactandrate 对乳腺癌细胞具有生长抑制作用，GI50 值在 5-65 μM 之间。Lactandrate 在小鼠乳腺肿瘤 (MXT 和 CD8F1) 以及人类异种移植 MX-1 中具有抗肿瘤活性。

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Lactandrate

Lactandrate Chemical Structure

CAS No. : 43000-65-3

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Lactandrate 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Hs 766 IC50
> 100 μM
Compound: 104
Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay
Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay
[PMID: 29649739]
MCF7 GI50
5 μM
Compound: 104
Growth inhibition of human MCF7 cells after 48 by MTT assay
Growth inhibition of human MCF7 cells after 48 by MTT assay
[PMID: 29649739]
MIA PaCa-2 IC50
> 100 μM
Compound: 104
Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay
Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay
[PMID: 29649739]
PANC-1 IC50
> 100 μM
Compound: 104
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay
[PMID: 29649739]
T47D GI50
5 μM
Compound: 104
Growth inhibition of human T47D cells after 48 by MTT assay
Growth inhibition of human T47D cells after 48 by MTT assay
[PMID: 29649739]
分子量

563.60

Formula

C31H44Cl2N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lactandrate 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactandrate43000-65-3Estrogen Receptor/ERRInhibitorinhibitorinhibit

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