Liothyronine (Synonyms: 三碘甲状腺原氨酸; Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

目录号: HY-A0070AG: Data Sheet SDS 产品使用指南
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Liothyronine (Triiodothyronine) (GMP) 是 GMP 级别的 Liothyronine (HY-A0070A)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Liothyronine 是有效的 TRα 和 TRβ 激动剂，对 hTRα 和 hTRβ 的 K_i 值均为 2.33 nM。

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Liothyronine Chemical Structure

CAS No. : 6893-02-3

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生物活性
纯度 & 产品资料
参考文献

生物活性

Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively^[1].

IC₅₀ & Target

TRβ1^[1]^[2]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO	EC₅₀	3.4 nM Compound: T3	Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay	[PMID: 32356658]
CHO	EC₅₀	6.2 nM Compound: T3	Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay	[PMID: 32356658]
CHO-K1	IC₅₀	0.24 nM Compound: 1	Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells	[PMID: 17543524]
CHO-K1	IC₅₀	0.26 nM Compound: 1	Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells	[PMID: 17543524]
CV-1	EC₅₀	0.002 μM Compound: T3	Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay	[PMID: 24290064]
CV-1	EC₅₀	0.0021 μM Compound: T3	Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay	[PMID: 24290064]
CV-1	EC₅₀	0.5 nM Compound: T3	Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay	[PMID: 32356658]
CV-1	EC₅₀	1.2 nM Compound: T3	Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay	[PMID: 32356658]
HEK-293T	EC₅₀	5.8 μM Compound: T3	Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay	[PMID: 32356658]
HEK293	EC₅₀	0.41 nM Compound: T3	Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
HeLa	EC₅₀	2.4 nM Compound: T3	Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay	[PMID: 17988877]
HeLa	EC₅₀	2.4 nM Compound: T3	Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay	[PMID: 17988877]
LNCaP	IC₅₀	> 50 μM Compound: 6, T3	Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis	[PMID: 22047606]
Oocyte	IC₅₀	50.4 μM Compound: Triiodothyronine	TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytes	[PMID: 11561088]
Sf9	EC₅₀	0.5 nM Compound: T3	Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis	[PMID: 32356658]
U2OS	EC₅₀	11 nM Compound: T3	Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay	[PMID: 17988877]
U2OS	EC₅₀	2.4 nM Compound: T3	Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay	[PMID: 17988877]

体外研究
(In Vitro)

Liothyronine (GMP) 可用于诱导人角质形成细胞生成诱导性多能干细胞^[1]。
Liothyronine (GMP) 是角膜缘干细胞 (LSC) 增殖和自我更新所必需的^[2]。
Liothyronine (GMP) (4 nM) 促进胚胎干细胞的心脏分化和成熟^[3]。
Liothyronine (GMP) (100 nM，14 天) 促进人诱导多能干细胞 (hiPSC) 来源的心肌细胞的电生理成熟^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

650.97

Formula

C₁₅H₁₂I₃NO₄

CAS 号

6893-02-3

性状

固体

颜色

White to off-white

中文名称

三碘甲状腺原氨酸 (GMP)；碘噻罗宁 (GMP)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (533 KB) SDS (393 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Aasen T, et al. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Protoc. 2010 Feb;5(2):371-82. [Content Brief]

[2]. Yu M, et al. An important role for adenine, cholera toxin, hydrocortisone and triiodothyronine in the proliferation, self-renewal and differentiation of limbal stem cells in vitro. Exp Eye Res. 2016 Nov;152:113-122. [Content Brief]

[3]. CY, et al. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36. [Content Brief]

[4]. Wang L, et al. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Dec;161:130-138. [Content Brief]

Liothyronine 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Liothyronine (GMP)6893-02-3Triiodothyronine (GMP) 3,3',5-Triiodo-L-thyronine (GMP) T3 (GMP)三碘甲状腺原氨酸 (GMP) 碘噻罗宁 (GMP)Thyroid Hormone ReceptorTHRGMPcell therapydifferentiatestem cellLSCsInhibitorinhibitorinhibit

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营业执照（三证合一）

Liothyronine (Synonyms: 三碘甲状腺原氨酸; Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

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Liothyronine (Synonyms: 三碘甲状腺原氨酸; Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

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Liothyronine 相关分类

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